Skip to main content

Advertisement

Log in

Treatment Decision for Potential Bleeders in Obscure Gastrointestinal Bleeding During Double-Balloon Enteroscopy

  • Original Article
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

Double-balloon enteroscopy (DBE) is an effective tool for diagnosing and treating obscure gastrointestinal bleeding. The aim is to describe how outcomes differ with patient setting (with DBE diagnosis and intervention, with DBE diagnosis but without intervention, and without DBE diagnosis), and thus demonstrate the value of endoscopic intervention when encountering potential bleeder during DBE. From November 2003 to January 2008, 90 patients with obscure gastrointestinal bleeding presented with DBE at our tertiary referral center. A total of 113 DBE procedures were carried out. Overall diagnostic yield was 75.6% (68/90). Endoscopic intervention was performed in 58 (85.3%) of the 68 patients with potential bleeder. The 90 patients were divided into three settings: with endoscopic diagnosis and intervention (n = 58), with endoscopic diagnosis but without intervention (n = 10), and without endoscopic diagnosis (n = 22). Rebleeding rates for the three groups were 22.4%, 60%, and 22.7%, respectively. For the 35 patients diagnosed with vascular lesions, the rebleeding rates in patients with and without endoscopic intervention, were 38.5% (10/26) and 66.7% (6/9), respectively. One (0.9%) severe adverse event occurred during the 113 procedures, and the patient died. DBE is an effective tool for diagnosing and treating obscure gastrointestinal bleeding. DBE involves relatively safe procedures and has an acceptable complication rate. When potential bleeders are encountered during the procedure, especially for vascular lesions, therapeutic intervention should be attempted, since the intervention-related complication rate is acceptable, and such intervention can reduce the rebleeding rate and enhance the cost-effectiveness of DBE.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Gerson LB. Double-balloon enteroscopy: the new gold standard for small bowel imaging? Gastrointest Endosc. 2005;62:71–75. doi:10.1016/S0016-5107(05)00507-9.

    Article  PubMed  Google Scholar 

  2. Rockey DC. Occult gastrointestinal bleeding. N Engl J Med. 1999;341:38–46. doi:10.1056/NEJM199907013410107.

    Article  PubMed  CAS  Google Scholar 

  3. Underhill BM. Intestinal length in man. BMJ. 1955;2:1243–1246.

    Article  PubMed  CAS  Google Scholar 

  4. Hara AK, Leighton JA, Sharma VK, Fleischer DE. Small bowel: preliminary comparison of capsule endoscopy with barium study and CT. Radiology. 2004;230:260–265. doi:10.1148/radiol.2301021535.

    Article  PubMed  Google Scholar 

  5. Costamagna G, Shah SK, Riccioni ME, et al. A prospective trial comparing small bowel radiographs and video capsule endoscopy for suspected small bowel disease. Gastroenterology. 2002;123:999–1005. doi:10.1053/gast.2002.35988.

    Article  PubMed  Google Scholar 

  6. Gutierrez C, Mariano M, Vander Laan T, Wang A, Faddis DM, Stain SC. The use of technetium-labeled erythrocyte scintigraphy in the evaluation and treatment of lower gastrointestinal hemorrhage. Am Surg. 1998;64:989–992.

    PubMed  CAS  Google Scholar 

  7. Rollins ES, Picus D, Hicks ME, Darcy MD, Bower BL, Kleinhoffer MA. Angiography is useful in detecting the source of chronic gastrointestinal bleeding of obscure origin. AJR Am J Roentgenol. 1991;156:385–388.

    PubMed  CAS  Google Scholar 

  8. Hayat M, Axon T, O’Mahony S. Diagnosti yield and effect on clinical outcomes of push enteroscopy in suspected small-bowel bleeding. Endoscopy. 2000;32:369–372. doi:10.1055/s-2000-9003.

    Article  PubMed  CAS  Google Scholar 

  9. Descamps C, Schmit A, Van Gossum A. Missed upper gastrointestinal tract lesions may explain occult bleeding. Endoscopy. 1999;31:452–455. doi:10.1055/s-1999-151.

    Article  PubMed  CAS  Google Scholar 

  10. Zaman A, Sheppard B, Katon RM. Total peroral intraoperative enteroscopy for obscure gastrointestinal bleeding using a dedicated push enteroscope: diagnostic yield and patient outcome. Gastrointest Endosc. 1999;50:506–510. doi:10.1016/S0016-5107(99)70073-8.

    Article  PubMed  CAS  Google Scholar 

  11. Lewis BS, Swain P. Capsule endoscopy in the evaluation of patients with suspected small intestinal bleeding: result of a pilot study. Gastrointest Endosc. 2002;56:349–353. doi:10.1016/S0016-5107(02)70037-0.

    Article  PubMed  Google Scholar 

  12. Ell C, Remke S, May A, Helou L, Henrich R, Mayer G. The first prospective controlled trial comparing wireless capsule endoscopy with push enteroscopy in chronic gastrointestinal bleeding. Endoscopy. 2002;34:865–869. doi:10.1055/s-2002-33446.

    Article  Google Scholar 

  13. Saurin JC, Delvaux M, Gaudin JL, Fassler I, Villarejo J, Vahedi G. Diagnostic value of endoscopic capsule in patients with obscure digestive bleeding: blinded comparison with video push enteroscopy. Endoscopy. 2003;35:576–584. doi:10.1055/s-2003-38767.

    Article  PubMed  Google Scholar 

  14. Yamamoto H, Sekine Y, Sato Y, et al. Total enteroscopy with a nonsurgical steerable double-balloon method. Gastrointest Endosc. 2001;53:216–220. doi:10.1067/mge.2001.112181.

    Article  PubMed  CAS  Google Scholar 

  15. Su MY, Liu NJ, Hsu CM, Chiu CT, Chen PC, Lin CJ. Double balloon enteroscopy-the last blind-point of the gastrointestinal tract. Dig Dis Sci. 2005;56:62–70.

    Google Scholar 

  16. Hsu CM, Chiu CT, Su MY, Lin WP, Chen PC, Chen CH. The outcome assessment of double-balloon enteroscopy for diagnosing and managing patients with obscure gastrointestinal bleeding. Dig Dis Sci. 2007;62:162–166. doi:10.1007/s10620-006-9554-x.

    Article  Google Scholar 

  17. Sun B, Rajan E, Cheng S, et al. Diagnostic yield and therapeutic impact of double-balloon enteroscopy in a large cohort of patients with obscure gastrointestinal bleeding. Am J Gastroenterol. 2006;101:2011–2015. doi:10.1111/j.1572-0241.2006.00664.x.

    Article  PubMed  Google Scholar 

  18. Yamamoto H, Kita H, Sunada K, et al. Clinical outcomes of double-balloon endoscopy for the diagnosis and treatment of small intestinal disease. Clin Gastroenterol Hepatol. 2004;2:1010–1016. doi:10.1016/S1542-3565(04)00453-7.

    Article  PubMed  Google Scholar 

  19. Manabe N, Tanaka S, Fukumoto A, Makao M, Kanimo D, Chayama K. Double-balloon enteroscopy in patients with GI bleeding. Gastrointest Endosc. 2006;64:135–140. doi:10.1016/j.gie.2005.12.020.

    Article  PubMed  Google Scholar 

  20. May A, Nachbar L, Pohl J, Ell C. Endoscopic interventions in the small bowel using double balloon enteroscopy: feasibility and limitations. Am J Gastroenterol. 2007;102:527–535. doi:10.1111/j.1572-0241.2007.01063.x.

    Article  PubMed  Google Scholar 

  21. May A, Nachbar L, Ell C. Double-balloon enteroscopy (push-and–pull enteroscopy) of the small bowel: feasibility and diagnostic and therapeutic yield in patients with suspected small bowel disease. Gastrointest Endosc. 2005;62:62–70. doi:10.1016/S0016-5107(05)01586-5.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ming-Yao Su.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lin, WP., Chiu, CT., Su, MY. et al. Treatment Decision for Potential Bleeders in Obscure Gastrointestinal Bleeding During Double-Balloon Enteroscopy. Dig Dis Sci 54, 2192–2197 (2009). https://doi.org/10.1007/s10620-008-0591-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-008-0591-5

Keywords

Navigation