Skip to main content
SpringerLink
Log in

Conjugated Linoleic Acid-Induced Toxic Hepatitis: First Case Report

  • CASE REPORT
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

A 46-year-old female patient was referred to our department with presenting symptoms of asthenia, jaundice, and pruritus. There was no medical history or clinical evidence of viral hepatitis, autoimmune hepatitis, hemochromatosis, or Wilson’s disease. The patient revealed that 14 days prior to admission she had begun self-medicating with conjugated linoleic acid (CLA) to reduce body fat, leading to the suspicion of CLA hepatotoxicity, which was subsequently confirmed by a liver biopsy. After the patient ceased to ingest CLA, liver enzymes levels normalized. To the best of our knowledge, this is the first report of hepatotoxicity due to CLA ingestion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Millonig G, Stadlmann S, Vogel W. Herbal hepatotoxicity: acute hepatitis caused by Noni preparation (Morinda citrifolia). Eur J Gastroenterol Hepatol. 2005;17(4):445–447. doi:10.1097/00042737-200504000-00009.

    Article  PubMed  Google Scholar 

  2. Ostapowicz GA, Fontana RJ, Schiodt FV, et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med. 2002;137:947–954.

    PubMed  Google Scholar 

  3. Larrey D. Hepatotoxicity of herbal remedies. J Hepatol. 1997;26[Suppl 1]:47–51. doi:10.1016/S0168-8278(97)82333-1.

    Article  PubMed  CAS  Google Scholar 

  4. Stadlbauer V, Fickert P, Lackner C, et al. Hepatotoxicity of NONI juice: report of two cases. World J Gastroenterol. 2005;11(30):4758–4760.

    PubMed  Google Scholar 

  5. Boullata JI, Nace AM. Safety issues with herbal medicine. Pharmacotherapy. 2000;20:257–269. doi:10.1592/phco.20.4.257.34886

    Article  PubMed  CAS  Google Scholar 

  6. Larrey D. Drug-induced liver diseases. J Hepatol. 2000;32[Suppl 1]:77–88. doi:10.1016/S0168-8278(00)80417-1.

    Article  PubMed  CAS  Google Scholar 

  7. Larrey D. Epidemiology and individual susceptibility to adverse drug reactions affecting the liver. Semin Liver Dis. 2002;22(2):145–155. doi:10.1055/s-2002-30101.

    Article  PubMed  CAS  Google Scholar 

  8. Danan G, Benichou C. Causality assessment of adverse reactions to drugs—I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol. 1993;46(11):1323–1330. doi:10.1016/0895-4356(93)90101-6.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Gastroenterology Department, Covilhã University Hospital, Quinta do Alvito, 6000-251, Covilhã, Portugal

    Rui Ramos, Joana Mascarenhas, Patrícia Duarte, Célia Vicente & Carlos Casteleiro

Authors
  1. Rui Ramos
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Joana Mascarenhas
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Patrícia Duarte
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Célia Vicente
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Carlos Casteleiro
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rui Ramos.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ramos, R., Mascarenhas, J., Duarte, P. et al. Conjugated Linoleic Acid-Induced Toxic Hepatitis: First Case Report. Dig Dis Sci 54, 1141–1143 (2009). https://doi.org/10.1007/s10620-008-0461-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-008-0461-1

Keywords

Search

Navigation