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Bispectral Index Monitoring for Nurse-Administered Propofol Sedation During Upper Endoscopic Ultrasound: A Prospective, Randomized Controlled Trial

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Abstract

Bispectral index monitoring (BIS) is a quantitative assessment of brain cortical activity. The aim of this study was to determine if BIS-guided nurse-administered propofol sedation would decrease by ≥20% both recovery time and propofol dose compared to standard propofol sedation for endoscopic ultrasound (EUS). Prospectively, eligible outpatients were randomized to BIS-guided or standard propofol sedation during EUS. Propofol was given by nurses in intermittent boluses with sedation targeted at a BIS score of <65–75. For the control group, the nurse was blinded to BIS scores and sedation was titrated to a modified observer’s assessment of alertness/sedation scale (MOAA/S) score ≤3. Of 50 patients enrolled, data for 44 randomized to BIS-guidance (n = 24) and the control group (n = 20) were evaluated. Between the BIS-guided and control group there was no difference between the mean procedure duration, total propofol dose, recovery time, mean intraoperative MOAA/S, and mean BIS score. Compared to standard propofol sedation for EUS, BIS-guided propofol sedation offers no significant decrease in postprocedure recovery times or propofol doses.

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Acknowledgements

This Grant was supported by Aspect Medical Systems, Inc., Norwood, MA.

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Authors and Affiliations

  1. Indiana University School of Medicine, Indianapolis, IN, USA

    John M. DeWitt

  2. Department of Gastroenterology and Hepatology, Indiana University Medical Center, Indianapolis, IN, USA

    John M. DeWitt

  3. Division of Gastroenterology, Department of Internal Medicine, Indiana University Medical Center, 550 N. University Blvd., UH 4100, Indianapolis, IN, 46202-5121, USA

    John M. DeWitt

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Correspondence to John M. DeWitt.

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DeWitt, J.M. Bispectral Index Monitoring for Nurse-Administered Propofol Sedation During Upper Endoscopic Ultrasound: A Prospective, Randomized Controlled Trial. Dig Dis Sci 53, 2739–2745 (2008). https://doi.org/10.1007/s10620-008-0198-x

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  • DOI: https://doi.org/10.1007/s10620-008-0198-x

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