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Matrix Metalloproteinase (MMP)-3 Polymorphism in Patients with HBV Related Chronic Liver Disease

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Abstract

A common and important problem in patients with chronic hepatitis B is the progression of liver fibrosis. Matrix metalloproteinases (MMPs) play an important role in the progression of liver fibrosis. Our aim of this study was to examine the association of MMP-3 polymorphism with liver cirrhosis in Korean patients with chronic hepatitis B. Genomic DNA was extracted from 127 patients with chronic hepatitis B (CHB), 92 patients with hepatitis B virus (HBV)-related liver cirrhosis (HBV-LC), and 146 healthy subjects. MMP-3 polymorphism was determined by polymerase-chain reaction-based assays, and the association with the progression of liver cirrhosis was investigated. With regard to MMP-3 polymorphism, there was no statistical difference in genotype distributions among the three groups. However, the peripheral platelet count of the 5A carriers was significantly lower than that of the 6A homozygotes in the HBV-LV group (85.0 ± 36.9 vs. 109.8 ± 47.0 × 109/l; P = 0.02). With MMP-3 promoter polymorphism (rs3025058), a lower peripheral blood platelet count, which was related to advanced liver cirrhosis, was observed in 5A carriers. Therefore, more studies of MMP-3 gene polymorphism with larger populations should be conducted to further understand its role in the progression of liver cirrhosis.

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Authors and Affiliations

  1. Department of Internal Medicine, East-West Neo Medical Center, Kyung Hee University College of Medicine, Gangdong-gu, Seoul, 134-090, Korea

    Hyun Phil Shin, Joung Il Lee, Hyun Jeong Kim, Jae Myung Cha, Jong Beom Park & Kwang Ro Joo

  2. Department of Pharmacology, Kyung Hee University College of Medicine, Seoul, Korea

    Joo-Ho Jung & Sung-Vin Yim

  3. Department of Internal Medicine and Institute for Medical Science, Keimyung University School of Medicine, Daegu, Korea

    Jae Seok Hwang & Byoung-Kuk Jang

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  1. Hyun Phil Shin
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  2. Joung Il Lee
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Correspondence to Joung Il Lee.

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Shin, H.P., Lee, J.I., Jung, JH. et al. Matrix Metalloproteinase (MMP)-3 Polymorphism in Patients with HBV Related Chronic Liver Disease. Dig Dis Sci 53, 823–829 (2008). https://doi.org/10.1007/s10620-007-9937-7

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  • DOI: https://doi.org/10.1007/s10620-007-9937-7

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