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Mcp-1, eNOS, tPA and PAI-1 Gene Polymorphism and Correlation of Genotypes and Phenotypes in Hepatopulmonary Syndrome

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Abstract

Aim The aim of this case–control study was to investigate both the distribution of MCP-1, eNOS, tPA and PAI-1 gene polymorphism and correlation of genotypes and phenotypes. Method Between September 1997-January 2005, 20 patients with HPS (group 1) were compared with a group of cirrhotic patients (group 2, n = 19) as well as unrelated healthy controls (group 3, n = 59) in respect to MCP1, eNOS, tPA and PAI-1 gene polymorphism frequency distribution. Results MCP1-2518G allele carriage in patients with HPS was higher than in controls (P = 0.01). In non-HPS cirrhotic patients, eNOS Glu298Asp, Asp gene carriers and frequency of Asp alleles were detected to be considerably higher than in patients with HPS and healthy controls (P < 0.05). Conclusion HPS is more common in patients with MCP-1 2518G gene carriage; conversely it is less frequent in patients with high frequency of eNOS 298Asp allele and eNOS 298Asp carriage.

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Authors and Affiliations

  1. Department of Pediatric Gastroenterology, Hepatology and Nutrition and Organ Transplantation and Research Center, Ege University School of Medicine, Izmir, 35100, Turkey

    Gokhan Tumgor, Cigdem Arikan & Sema Aydogdu

  2. Molecular Biology Laboratory, Ege University School of Medicine, Izmir, Turkey

    Afig Berdeli

  3. Department of Pediatric Cardiology, Ege University School of Medicine, Izmir, Turkey

    Ertürk Levent

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  1. Gokhan Tumgor
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  2. Afig Berdeli
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Correspondence to Gokhan Tumgor.

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Tumgor, G., Berdeli, A., Arikan, C. et al. Mcp-1, eNOS, tPA and PAI-1 Gene Polymorphism and Correlation of Genotypes and Phenotypes in Hepatopulmonary Syndrome. Dig Dis Sci 53, 1345–1351 (2008). https://doi.org/10.1007/s10620-007-0002-3

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