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Can Soluble Triggering Receptor Expressed on Myeloid Cells (sTREM-1) Be Considered an Anti-Inflammatory Mediator in the Pathogenesis of Peptic Ulcer Disease?

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Abstract

Soluble triggering receptor expressed on myeloid cells (sTREM-1) is a novel mediator involved in the pathogenesis of peptic ulcer disease. To investigate the potential role of sTREM-1 in the anti-inflammatory response in chronic gastritis, sTREM-1 was compared with other anti-inflammatory mediators of gastritis. Forty patients with dyspepsia were enrolled: 20 with peptic ulcer and 20 controls without any macroscopic abnormalities. All patients were examined by endoscopy; gastric juice was aspirated and biopsy specimens were collected from the antrum and corpus of the stomach. sTREM-1, interleukin (IL)-8, and IL-10 were estimated by enzyme immunoassays. Median sTREM-1 in patient controls and in patients with peptic ulcer disease was 3.91 and 44.27 pg/ml, respectively (P=0.006). Respective values of IL-8 were 1856.97 and 2030.66 pg/ml (P=0.023); those of IL-10 were 16.92 and 18.43 pg/ml (NS). The odds ratio for the presence of peptic ulcer in the event of a concentration of sTREM-1 higher than 15 pg/ml was 23.22 (95% CI, 2.58–208.62; P=0.002). A positive correlation was found between the ratios of IL-8/sTREM-1 and IL-8/IL-10 (r s, + 0.365; P=0.021). In conclusion, sTREM-1 is an independent factor for the generation of peptic ulcer disease and might behave as an anti-inflammatory mediator in chronic gastritis.

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Authors and Affiliations

  1. Department of Gastroenterology, Sismanoglion General Hospital of Athens, Athens, Greece

    Vassilios Koussoulas, Spyridon Vassilliou & Charalambos Barbatzas

  2. Department of Pathophysiology, Gastroenterology Section, Athens Medical School, Athens, Greece

    Michalis Tzivras

  3. Fourth Department of Internal Medicine, Athens Medical School, Athens, Greece

    Evangelos J. Giamarellos-Bourboulis, Aimilia Pelekanou, Antonios Papadopoulos & Helen Giamarellou

  4. Department of Pathology, Sismanoglion General Hospital of Athens, Athens, Greece

    Maria Demonakou

  5. Sismanoglion General Hospital, 1 Sismanogliou Street, Athens, 151 26, Greece

    Vassilios Koussoulas

Authors
  1. Vassilios Koussoulas
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  2. Michalis Tzivras
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  3. Evangelos J. Giamarellos-Bourboulis
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  4. Maria Demonakou
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  5. Spyridon Vassilliou
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  6. Aimilia Pelekanou
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  7. Antonios Papadopoulos
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  8. Helen Giamarellou
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  9. Charalambos Barbatzas
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Correspondence to Vassilios Koussoulas.

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Koussoulas, V., Tzivras, M., Giamarellos-Bourboulis, E.J. et al. Can Soluble Triggering Receptor Expressed on Myeloid Cells (sTREM-1) Be Considered an Anti-Inflammatory Mediator in the Pathogenesis of Peptic Ulcer Disease?. Dig Dis Sci 52, 2166–2169 (2007). https://doi.org/10.1007/s10620-006-9694-z

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  • DOI: https://doi.org/10.1007/s10620-006-9694-z

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