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Adult-Onset Autoimmune Enteropathy in the Setting of Thymoma Successfully Treated with Infliximab

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References

  1. Walker-Smith JA, Unsworth DJ, Hutchins P, Philips AD, Holborow EJ: Autoantibodies against gut epithelium in a child with small intestinal enteropathy. Lancet 1:655–657, 1982

    PubMed  Google Scholar 

  2. Unsworth J, Hutchins P, Mitchell J: Flat small intestinal mucosa and autoantibodies against the gut epithelium. J Pediatr Gastroenterol Nutr 1:502–513, 1982

    Google Scholar 

  3. Unsworth DJ, Walker-Smith JA: Autoimmunity in diarrheal disease. J Pediatr Gastroenterol Nutr 4:375–380, 1985

    Article  CAS  PubMed  Google Scholar 

  4. León F, Olivencia P, Rodríguez-Pena R: Clinical and immunological features of the adult-onset generalized autoimmune gut disorder: Am J Gastroenterol 99:1563–1571, 2004

    PubMed  Google Scholar 

  5. Catassi C, Mirakian R, Natalini G, Sbarbati A, Cinti S, Coppa GV, Giorgi PL: Unresponsive enteropathy associated with circulating enterocyte autoantibodies in a boy with common variable hypogammaglobulinemia and type I diabetes: J Pediatr Gastroenterol Nutr 7:608–613, 1988

    CAS  PubMed  Google Scholar 

  6. Biagi F and Corazza GR: Invited commentary: Digestion 68:86–90, 2003

    PubMed  Google Scholar 

  7. Corazza GR, Biagi R, Volta U, Andreani ML, De Franceschi L, Gasbarrini G: Autoimmune enteropathy and villous atrophy in adults: Lancet 350:106–109, 1997

    CAS  PubMed  Google Scholar 

  8. Russo PA, Brochu P, Seidman EG, Roy CC: Autoimmune enteropathy. Pediatr Dev Pathol 2:65–71, 1999

    CAS  PubMed  Google Scholar 

  9. Carroccio A, Volta U, Di Prima L, Petrolini N, Florena AM, Averna MR, Montalto G, Notarbartolo A: Autoimmune enteropathy and colitis in an adult patient. Dig Dis Sci 68:86–90, 2003

    Google Scholar 

  10. Sanderson IR, Phillips AD, Spencer J, Walker-Smith JA: Response to autoimmune enteropathy of cyclosporine A therapy. Gut 32:1421–1425, 1991

    CAS  PubMed  Google Scholar 

  11. Mais DD, Milhall BP, Adolphson KR, Yamamoto K: Thymoma-associated autoimmune enteropathy. Am J Clin Pathol 112:810–815, 1999

    CAS  PubMed  Google Scholar 

  12. Kornacki S, Hansen FC, Lazenby A: Graft-versus-host-like colitis associated with malignant thymoma. Am J Surg Pathol 19:224–228, 1995

    Article  CAS  PubMed  Google Scholar 

  13. Sherman JD, Banas JS Jr, Edwards TL, MacMahon HE. Patterson JF: A syndrome of diarrhea, thymoma, and hypogammaglobulinemia. Gastroenterology 51:681–688, 1966

    CAS  PubMed  Google Scholar 

  14. Gupta S, Saverymuttu SH, Gibbs JS, Evans DJ, Hodgson HJ: Watery diarrhea in a patient with myasthenia gravis, thymoma, and immunodeficiency. Am J Gastroenterol 80:877–881, 1985

    CAS  PubMed  Google Scholar 

  15. Lowry PW, Myers JD, Geller A, Bostwick DG, Clain JE: Graft-versus-host-like colitis and malignant thymoma. Dig Dis Sci 47:1998–2001, 2002

    PubMed  Google Scholar 

  16. Verne GN, Amann ST, Cosgrove C, Cerda JJ: Chronic diarrhea associated with thymoma and hypogammaglobulinemia (Good’s syndrome). South Med J 90:444–446, 1997

    CAS  PubMed  Google Scholar 

  17. Daum S, Sahin E, Jansen A, Heine B, Riecken E, Zeitz M, Schmidt W: Adult autoimmune enteropathy treated successfully with tacrolimus. Digestion 68:86–90, 2003

    PubMed  CAS  Google Scholar 

  18. Rolny P, Sigurijondottir HA, Remotti H, Nilsson LA, Ascher H, Tlaskalova-Hogenova H, Tuckova L: Role of immunosuppressive therapy in refractory sprue-like disease. Am J Gastroenterol 94:219–225, 1999

    CAS  PubMed  Google Scholar 

  19. Vanderhoof JA, Young RJ: Autoimmune enteropathy in a child: response to inflixamab therapy. J Pediatr Gastroenterol Nutr 34:312–316, 2002

    Article  PubMed  Google Scholar 

  20. Casos B, Fernandez-Vazquez I, Bernados E, Ballestin C, Morillas JD, Colina F, Solis-Herruzo JA: Autoimmune enteropathy in an adult with autoimmune multisystemic involvement. Scand J Gastroenterol 37:1012–1016, 2002

    Article  PubMed  Google Scholar 

  21. Kuuse R, Labotkin K, Metskula K: A case of unclassified sprue—An adult form of autoimmune enteropathy? Dept Intern Med, Tartu University; http://www.kenes.com/autoim2002/Scientific/243.doc, 2002 (abstract)

  22. Hori K, Fukuda Y, Tomita T, Kosaka T, Tamura K, Nishigami T, Kubota A, Shimoyama T: Intestinal goblet cell autoantibody associated enteropathy. Scand J Gastroenterol 37:1012–1016, 2002

    Article  PubMed  Google Scholar 

  23. Mitomi H, Tannabe S, Igarashi M, Katsumata T, Arai N, Kikuchi S, Kiyohashi A, Okayasu I: Autoimmune enteropathy with severe atrophic gastritis and colitis in an adult: proposal of a generalized autoimmune disorder of the alimentary tract. Scand J Gastroenterol 33:716–720, 1998

    Article  CAS  PubMed  Google Scholar 

  24. Beck MN, Kuchler H, Roulet M, Beck D: Prolonged remission induced by cyclosporine in a patient with familial thrombocytopenia and enteropathy. Pediatr Hematol Oncol 12:289–293, 1995

    CAS  PubMed  Google Scholar 

  25. Horvath K, Fasano A: Management of refractory celiac disease. Medscape Gen Med; www.medscape.com 3, 2001

  26. Van Deventer SJ: Tumour necrosis factor and Crohn’s disease. Gut 40:443–448, 1997

    CAS  PubMed  Google Scholar 

  27. Gillett HR, Arnott ID, McIntyre M, Campbell S, Dahele A, Priest M, Jackson R, Ghosh S: Successful infliximab treatment for steroid-refractory celiac disease: a case report. Gastroenterology 122:800–805, 2002

    PubMed  Google Scholar 

  28. ten Hove T, van Montfrans C, Peppelenbosch MP, van Deventer SJH: Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn’s disease. Gut 50:206–211, 2002

    Article  CAS  PubMed  Google Scholar 

  29. Lexi-Comp Online: http://www.crlonline.com/crlsql/servlet/crlonline

  30. Barshes NR, Goodpastor SE, Goss JA: Pharmacologic immunosuppression. Frontiers Biosci 9:411–420, 2004

    CAS  Google Scholar 

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Correspondence to Ray E. Clouse MD.

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Elwing, J.E., Clouse, R.E. Adult-Onset Autoimmune Enteropathy in the Setting of Thymoma Successfully Treated with Infliximab. Dig Dis Sci 50, 928–932 (2005). https://doi.org/10.1007/s10620-005-2666-x

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  • DOI: https://doi.org/10.1007/s10620-005-2666-x

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