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Hypolipidemic Activity of Monacolin Derivatives from the Highland Barley Monascus purpureus

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Chemistry of Natural Compounds Aims and scope

A new monacolin derivative, namely (1S,2S,5′R,6R,8aR)-7-hydroxy-2,6-dimethyl-8-prenyl-1,2,6,8atetrahydronaphthalene-4′,5′-dihydro-2H-pyran-1′-one (1), and five known monacolin derivatives (2–6) were separated from the highland barley Monascus purpureus Went. for the first time. Their structures were elucidated on the basis of 1D and 2D NMR, HR-ESI-MS, and relevant references. Compounds 1–6 were tested for their hypolipidemic activities by measuring the triglyceride content in HepG2 cells. Among them, compounds 1 and 2 (10 μM) exhibited moderate hypolipidemic activity.

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Acknowledgment

This study was supported by the Science and Technology Project of Jiangxi Provincial Department of Education (GJJ180688).

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Authors and Affiliations

  1. Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Key Laboratory of Modern Preparation of TCM of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, 330004, Nanchang, P. R. China

    Rongrui Wei, Qinge Ma, Wei Jiang & Guoyue Zhong

  2. College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, 473061, Nanyang, P. R. China

    Zhipei Sang

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  1. Rongrui Wei
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  2. Qinge Ma
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  3. Wei Jiang
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  4. Guoyue Zhong
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  5. Zhipei Sang
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Corresponding author

Correspondence to Qinge Ma.

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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2020, pp. 920–922.

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Wei, R., Ma, Q., Jiang, W. et al. Hypolipidemic Activity of Monacolin Derivatives from the Highland Barley Monascus purpureus. Chem Nat Compd 56, 1072–1075 (2020). https://doi.org/10.1007/s10600-020-03229-2

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  • DOI: https://doi.org/10.1007/s10600-020-03229-2

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