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Synthesis of Monosubstituted Purpurins and Their Biological Activity

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Products were obtained from acylation of 1,2,4-trihydroxy-9,10-anthraquinone (purpurin) by saturated cyclic carboxylic acid chlorides. The compositions and structures of the monosubstituted compounds were confirmed by elemental analysis and IR and PMR spectroscopy. The cytotoxicities of the derivatives were evaluated in an Artemia salina Leach brine shrimp test.

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Acknowledgment

The work was financially supported by the Science Committee, Ministry of Education and Science of the Republic of Kazakhstan, under contract No. 83 (Appendix 1.7) dated March 2, 2018, in the framework of the project on “Search for new drugs based on available synthetic analogs of natural anthraquinone derivatives” (IRN AR05131788).

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Authors and Affiliations

  1. JSC “A. B. Bekturov Institute of Chemical Sciences”, 106 Sh. Walikhanov St., Almaty, Republic of Kazakhstan, 050010

    T. V. Kharlamova, R. B. Seidakhmetova & K. D. Praliev

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  1. T. V. Kharlamova
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  2. R. B. Seidakhmetova
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  3. K. D. Praliev
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Correspondence to T. V. Kharlamova.

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Translated from Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2019, pp. 536–538.

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Kharlamova, T.V., Seidakhmetova, R.B. & Praliev, K.D. Synthesis of Monosubstituted Purpurins and Their Biological Activity. Chem Nat Compd 55, 622–625 (2019). https://doi.org/10.1007/s10600-019-02763-y

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  • DOI: https://doi.org/10.1007/s10600-019-02763-y

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