Two new isoflavones, 6-hydroxy-7-(3-hydroxypropyl)-4′-methoxyisoflavone (1) and 6,4′-dihydroxy-7-(3-hydroxypropyl)-isoflavone (2), were isolated from the flowers of Rosa damascena. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compounds 1 and 2 showed weak inhibition with IZD of 11.6 ± 1.2 and 11.2 ± 1.0 mm, respectively. Compounds 1 and 2 were also tested for their antioxidant activity and showed good activity with an IC50 value of 4.2 and 4.0 μg/mL, respectively.
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Acknowledgment
This research was supported by the Research Foundation of China Tobacco Company (No. 110201502006), the Research Foundation of China Tobacco Yunnan Industrial Co., Ltd. (Nos. 2015539200340277, 2016JC03, and JSZX20151008-52), the National Natural Science Foundation of China (Nos. 81660717 and 21462051), and the Natural Science Foundation of Yunnan Province (No. 2014FD033).
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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2019, pp. 386–389.
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Xiang, HY., Xing, HH., Li, J. et al. Two New Isoflavones from the Flowers of Rosa damascena and Their Biological Activities. Chem Nat Compd 55, 449–452 (2019). https://doi.org/10.1007/s10600-019-02711-w
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DOI: https://doi.org/10.1007/s10600-019-02711-w