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A New Amide and Antioxidant Constituents of Piper taiwanense

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Chemistry of Natural Compounds Aims and scope

A new amide, pipertaiwanamide (1), has been isolated from the aerial part of Piper taiwanense, together with four known compounds, taiwanamide A (2), taiwanamide B (3), 1-cinnamoylpyrrolidine (4), and N-cinnamoyltyramine (5). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Pipertaiwanamide (1) and N-cinnamoyltyramine (5) exhibited free radical scavenging activity, with IC0.200 values of 12.6 ± 1.4 and 8.5 ± 0.8 𝜇M, respectively, in the diphenylpicrylhydrazyl radical (DPPH) decoloration assay.

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Acknowledgment

This research was supported by a grant from the Ministry of Science and Technology, Taiwan (NSC 101-2320-B-127-001-MY3), awarded to Prof. J.-J. Chen.

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Authors and Affiliations

  1. Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, 112, Taipei, Taiwan

    Jih-Jung Chen

  2. Department of Medical Research, China Medical University Hospital, 404, Taichung, Taiwan

    Jih-Jung Chen

  3. Department of Medicine, Mackay Medical College, New Taipei City, 252, Taiwan

    Shih-Wei Wang

  4. Department of Biological Sciences, National Sun Yat-sen University, 804, Kaohsiung, Taiwan

    Chun-Lin Chen

  5. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, 404, Taichung, Taiwan

    Yueh-Hsiung Kuo

  6. Department of Biotechnology, Asia University, 413, Taichung, Taiwan

    Yueh-Hsiung Kuo

  7. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), 300, Hsinchu, Taiwan

    Ming-Jen Cheng

  8. Department of Medical Education and Research, Kaohsiung Veterans General Hospital, 813, Kaohsiung, Taiwan

    Tsung-Hsien Chang

  9. National Museum of Marine Biology and Aquarium, 944, Pingtung, Taiwan

    Ping-Jyun Sung

  10. Chung-Jen Junior College of Nursing, Health Sciences and Management, 600, Chiayi, Taiwan

    Wen-Lung Kuo

  11. School of Pharmacy, College of Pharmacy, China Medical University, 404, Taichung, Taiwan

    Yun-Ping Lim

Authors
  1. Jih-Jung Chen
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  2. Shih-Wei Wang
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  3. Chun-Lin Chen
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  4. Yueh-Hsiung Kuo
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  5. Ming-Jen Cheng
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  6. Tsung-Hsien Chang
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  7. Ping-Jyun Sung
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  8. Wen-Lung Kuo
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  9. Yun-Ping Lim
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Corresponding author

Correspondence to Jih-Jung Chen.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2017, pp. 949–952.

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Chen, JJ., Wang, SW., Chen, CL. et al. A New Amide and Antioxidant Constituents of Piper taiwanense . Chem Nat Compd 53, 1117–1121 (2017). https://doi.org/10.1007/s10600-017-2213-y

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  • DOI: https://doi.org/10.1007/s10600-017-2213-y

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