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New Metabolites from the Endophytic Fungus Mollisia sp.

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Chemistry of Natural Compounds Aims and scope

Two new metabolites, mollisinols A and B (1 and 2), and one first isolated from nature, mollisilactone (3), along with 13 known compounds (4–16), were isolated from the EtOAc-soluble fraction of the solid-state fermentation of the endophytic fungus Mollisia sp., derived from the root bark of Ardisia cornudentata Mez (Myrsinaceae). Their structures were elucidated by spectroscopic analyses, including 1D and 2D NMR experiments, and by HR-ESI-MS mass spectrometry. Among the isolates, ergosterol peroxide (12) inhibited NO production in activated macrophages, and emodin (8) showed IL-6 inhibitory activity in LPS activated RAW 264.7 cells with IC50 values of 36.99 and 5.97 μM, respectively.

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Acknowledgment

This investigation was supported by a grant from the Ministry of Economic Affairs of the Republic of China. The authors also thank Senior Technician Chyi-Jia Wang of the Center for Resources, Research and Development (CRRD) of Kaohsiung Medical University for measuring the 2D NMR data.

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Authors and Affiliations

  1. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, 807, Kaohsiung, Taiwan

    Nai Wen Fan & Hsun Shuo Chang

  2. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 807, Kaohsiung, Taiwan

    Hsun Shuo Chang & Ih Sheng Chen

  3. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), 300, Hsinchu, Taiwan

    Ming Jen Cheng, Hing Yuen Chan, Sung Yuan Hsieh, Ta Wei Liu & Gwo Fang Yuan

  4. Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, 807, Kaohsiung, Taiwan

    Sheng Wen Chen

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  1. Nai Wen Fan
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Correspondence to Ming Jen Cheng.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2016, pp. 508–512.

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Fan, N.W., Chang, H.S., Cheng, M.J. et al. New Metabolites from the Endophytic Fungus Mollisia sp.. Chem Nat Compd 52, 585–590 (2016). https://doi.org/10.1007/s10600-016-1718-0

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  • DOI: https://doi.org/10.1007/s10600-016-1718-0

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