Skip to main content
SpringerLink
Log in

New Esters of Aromatic Hydroxyl Acids from Moringa oleifera Roots

  • Published:
Chemistry of Natural Compounds Aims and scope

Chemical analysis of the acetone extract (MRA) of Moringa oleifera roots resulted in the isolation of two new esters. Their structures have been elucidated by extensive spectroscopic studies including 1H, 13C, and 2D NMR (DEPT, COSY, NOESY, HMQC, HMBC) spectroscopy. MRA showed a 47% fall in mean arterial blood pressure (MABP) at the dose of 30 mg/kg. Hypotensive activity was independent of cholinergic receptors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. S. Navie and S. Csurhes, Weed Risk Assessment Horseradish Tree Moringa oleifera, Biosecurity Queensland Department of Employment, Economic Development and Innovation, Brisbane 4001, Queensland State Education: Avoca, QLD, Australia, 2011, p. 1–22.

  2. J. W. Fahey, Trees Life J., 2, 1 (2005).

    Google Scholar 

  3. S. Faizi, B. S. Siddiqui, R. Saleem, K. Aftab, F. Shaheen, and A. H. Gilani, Planta Med., 64 (3), 225 (1998).

    Article  CAS  PubMed  Google Scholar 

  4. F. Alhakmani, S. Kumar, and S. A. Khan, Asian Pac. J. Trop. Biomed., 3, 623 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. H. Manaheji, S. Jafari, J. Zaringhalam, S. Rezazadeh, and R. Taghizadfarid, J. Chin. Integ. Med., 9, 216 (2011).

    Article  Google Scholar 

  6. K. V. Sashidhara, J. N. Rosaiah, E. Tyagi, R. Shukla, R. Raghubir, and S. M. Rajendran, Eur. J. Med. Chem., 44, 432 (2009).

    Article  CAS  PubMed  Google Scholar 

  7. P. Chumark, P. Khunawat, Y. Sanvarinda, S. Phornchirasilp, N. P. Morales, L. Phivthong-Ngam, P. Ratanachamnong, S. Srisawat, and K. U. Pongrapeeporn, J. Ethnopharmacol., 116 (3), 439 (2008).

    Article  PubMed  Google Scholar 

  8. R. V. Karadi, N. B. Gadge, K. R. Alagawadi, and R. V. Savadi, J. Ethnopharmacol., 105 (1–2), 306 (2006).

    Article  PubMed  Google Scholar 

  9. T. Marrufo, F. Nazzaro, E. Mancini, F. Fratianni, R. Coppola, L. De Martino, A. B. Agostinho, and V. De Feo, Molecules 18 (9), 10989 (2013).

    Article  CAS  PubMed  Google Scholar 

  10. E. P. Padla, L. T. Solis, R. M. Levida, C. C. Shen, and C. Y. Ragasa, Z. Naturforsch., 67c (11–12), 557 (2012).

    Article  Google Scholar 

  11. S. Cheenpracha, E. J. Park, W. Y. Yoshida, C. Barit, M. Wall, J. M. Pezzuto, and L. C. Chang, Bioorg. Med. Chem., 18 (17), 6598 (2010).

    Article  CAS  PubMed  Google Scholar 

  12. S. Faizi, B. S. Siddiqui, R. Saleem, S. Siddiqui, K. Aftab, and A. H. Gilani, Phytochemistry, 38 (4), 957 (1995).

    Article  CAS  PubMed  Google Scholar 

  13. A. P. Guevara, C. Vargas, H. Sakurai, Y. Fujiwara, K. Hashimoto, T. Maoka, M. Kozuka, Y. Ito, H. Tokuda, and H. Nishino, Mutat. Res., 440 (2), 181 (1999).

    Article  CAS  PubMed  Google Scholar 

  14. S. Panda, A. Kar, P. Sharma, and A. Sharma, Bioorg. Med. Chem. Lett., 23, 959 (2013).

    Article  CAS  PubMed  Google Scholar 

  15. S. Faizi, B. S. Siddiqui, R. Saleem, S. Siddiqui, K. Aftab, and A. H. Gilani, J. Nat . Prod., 57 (9), 1256 (1994).

  16. R. Saleem, M. Ahmed, S. I. Ahmed, M. Azeem, R. A. Khan, N. Rasool, H. Saleem, F. Noor, and S. Faizi, Phytother. Res., 19, 881 (2005).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, 74600, Karachi, Pakistan

    R. Saleem & A. Sana

  2. Dr. HMI Institute of Pharmacology & Herbal Sciences, Hamdard University, 74600, Karachi, Pakistan

    R. Saleem & F. Sadaf

  3. HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, 75270, Karachi, Pakistan

    S. Faizi

Authors
  1. R. Saleem
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Sana
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Faizi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. F. Sadaf
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to R. Saleem.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2016, pp. 183–186.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Saleem, R., Sana, A., Faizi, S. et al. New Esters of Aromatic Hydroxyl Acids from Moringa oleifera Roots. Chem Nat Compd 52, 208–212 (2016). https://doi.org/10.1007/s10600-016-1596-5

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10600-016-1596-5

Keywords

Search

Navigation