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Hypolipidemic Berberine Derivatives with a Reduced Aromatic Ring C

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Chemistry of Natural Compounds Aims and scope

A series of aromatic and reduced berberine derivatives were synthesized. Their hypocholesterolemic activity was studied in vitro and in vivo. As a rule, berberine derivatives containing a reduced ring C were more capable of increasing the LDL receptor gene expression than the corresponding aromatic derivatives. Tests using a Triton WR1339-induced hypercholesterolemia model showed that 9-O-tosyltetrahydroberberine and 12-bromotetrahydroberberine possessed pronounced hypocholesterolemic activity and reduced the total cholesterol level by 33 and 27%; the triglyceride level, by 25 and 26%, respectively.

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Acknowledgment

The work was sponsored by RFBR Project No. 15-03-10051.

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Authors and Affiliations

  1. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Prosp. Akad. Lavrent’eva, 9, Russia

    I. V. Nechepurenko, M. V. Khvostov, D. S. Baev, N. I. Komarova, T. G. Tolstikova & N. F. Salakhutdinov

  2. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Prosp. Akad. Lavrent’eva, 8, Russia

    U. A. Boyarskikh & M. L. Filipenko

Authors
  1. I. V. Nechepurenko
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  2. U. A. Boyarskikh
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  3. M. V. Khvostov
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  4. D. S. Baev
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  5. N. I. Komarova
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  6. M. L. Filipenko
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  7. T. G. Tolstikova
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  8. N. F. Salakhutdinov
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Corresponding author

Correspondence to I. V. Nechepurenko.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2015, pp. 786–791.

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Nechepurenko, I.V., Boyarskikh, U.A., Khvostov, M.V. et al. Hypolipidemic Berberine Derivatives with a Reduced Aromatic Ring C. Chem Nat Compd 51, 916–922 (2015). https://doi.org/10.1007/s10600-015-1447-9

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  • DOI: https://doi.org/10.1007/s10600-015-1447-9

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