Two new dihydroisocoumarin derivatives, aspergillumarins A and B (1 and 2), were isolated from the culture broth of a marine-derived fungus Aspergillus sp., which was isolated from the fresh leaf of the mangrove tree Bruguiera gymnorrhiza collected from the South China Sea. The structures of compounds 1 and 2 were established by comprehensive analysis of the spectral data, especially 2D NMR spectra results. Compounds 1 and 2 showed weak antibacterial activity against Staphylococcus aureus and Bacillus subtilis at a concentration of 50 μg/mL.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
J. W. Blunt, B. R. Copp, M. H. G. Munro, P. T. Northcote, and M. R. Prinsep, Nat. Prod. Rep., 23, 26 (2006).
T. S. Bugni and C. M. Ireland, Nat. Prod. Rep., 21, 143 (2004).
M. Saleem, M. S. S. Ali, J. A. Hussain, M. Ashraf, and Y. S. Lee, Nat. Prod. Rep., 24, 1142 (2007).
J. H. Pan, G. E. B. Jones, Z. G. She, J. Y. Pang, and Y. C. Lin, Bot. Mar., 51, 179 (2008).
C. L. Shao, Z. G. She, Z. Y. Guo, H. Peng, X. L. Cai, S. N. Zhou, Y. C. Gu, and Y. C. Lin, Magn. Reson. Chem., 45, 434 (2007).
C. L. Shao, C. Y. Wang, M. Y. Wei, Y. C. Gu, X. K. Xia, Z. G. She, and Y. C. Lin, Magn. Reson. Chem., 46, 1066 (2008).
C. L. Shao, C. Y. Wang, Y. C. Gu, M. Y. Wei, J. H. Pan, D. S. Deng, Z. G. She, and Y. C. Lin, Bioorg. Med. Chem. Lett., 20, 3284 (2010).
M. Y. Wei, C. Y. Wang, Q. A. Liu, C. L. Shao, Z. G. She, and Y. C. Lin, Mar. Drugs, 8, 941 (2010).
M. Devys, J. F. Bousquet, A. Kollmann, and M. Barbier, Phytochemistry, 19, 2221 (1980).
R. A. Fromtling, J. N. Galgiani, M. A. Pfaller, A. Espinel-Ingroff, K. F. Bartizal, M. S. Bartlett, B. A. Body, C. Frey, G. Hall, G. D. Roberts, F. B. Noltt, E. C. Odds, M. G. Rinaldi, A. M. Suger, and K. Villareal, Antimicrob. Agents Chemother., 37, 39 (1993).
Acknowledgment
This work was supported by the Open Research Fund Program of the Key Laboratory of Tropical Medicinal Plant Chemistry of the Ministry of Education, Hainan Normal University (Nos. 100304; 100305) and the Fund of the Key Scientific and Technical Innovation Project, Zhanjiang (No. 2009C3106011).
Author information
Authors and Affiliations
Corresponding author
Additional information
Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2012, pp. 337–339.
Rights and permissions
About this article
Cite this article
Li, S., Wei, M., Chen, G. et al. Two new dihydroisocoumarins from the endophytic fungus Aspergillus sp. collected from the south china sea. Chem Nat Compd 48, 371–373 (2012). https://doi.org/10.1007/s10600-012-0254-9
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10600-012-0254-9