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A Novel and Simple Synthesis of Ethers of Hydroxypyridines with Hexafluoropropan-2-ol via Diazotization of Aminopyridines and Aminoquinolines Under Acid-Free Conditions

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Chemistry of Heterocyclic Compounds Aims and scope

Herein, we report the first example of diazotization of aminopyridines and aminoquinolines with t-BuONO in hexafluoropropan-2-ol in the absence of acids or other initiators. For aminopyridines, this reaction is the first general route toward 2-, 3-, and 4-[(1,1,1,3,3,3-hexafluoropropan-2-yl)oxy]pyridines.

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Authors and Affiliations

  1. The Kizhner Research Center, National Research Tomsk Polytechnic University, 30 Lenina Ave, Tomsk, 634050, Russia

    Victor D. Filimonov, Aldar N. Sanzhiev, Roman O. Gulyaev & Elena A. Krasnokutskaya

  2. Department of Biomedicine, Altai State University, 61 Lenina Ave, Barnaul, 656049, Russia

    Alexander A. Bondarev

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  1. Victor D. Filimonov
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  2. Aldar N. Sanzhiev
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  3. Roman O. Gulyaev
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  4. Elena A. Krasnokutskaya
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  5. Alexander A. Bondarev
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Correspondence to Victor D. Filimonov.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2022, 58(12), 721–726

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Filimonov, V.D., Sanzhiev, A.N., Gulyaev, R.O. et al. A Novel and Simple Synthesis of Ethers of Hydroxypyridines with Hexafluoropropan-2-ol via Diazotization of Aminopyridines and Aminoquinolines Under Acid-Free Conditions. Chem Heterocycl Comp 58, 721–726 (2022). https://doi.org/10.1007/s10593-023-03148-4

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