A facile and efficient strategy for the synthesis of α,β-unsaturated lactams through ring-closing metathesis of easily prepared diene amides is being reported here. Reaction conditions were optimized for metathetic cyclization of diene amides to obtain five- to sevenmembered unsubstituted and β-substituted α,β-unsaturated lactams in good to excellent yield.
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H. Y. Gondal is thankful to Embassy of France in Pakistan for the financial support for postdoctoral studies at MNHN, Paris, France.
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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2016, 52(3), 183–191
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Gondal, H.Y., Buisson, D. A facile approach to α,β-unsaturated lactams by ring-closing metathesis. Chem Heterocycl Comp 52, 183–191 (2016). https://doi.org/10.1007/s10593-016-1858-y
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DOI: https://doi.org/10.1007/s10593-016-1858-y