The formyl group of 4H-thieno[3,2-c]chromene-2-carbaldehyde was transformed into the respective nitrile, amide, ester, carboxylic, hydroxamic, or hydroxy group. Electrophilic substitution in 4H-thieno[3,2-c]chromene-2-carbaldehyde was shown to occur at the С-8 atom, while oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone in methanol led to 4-methoxy-4H-thieno[3,2-c]chromene-2-carbaldehyde. The latter compound was found to possess high antiulcer activity.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1862–1868, December, 2014.
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Bogza, Y.P., Katsiel’, A.L., Sharypova, A.N. et al. Synthesis and Biological Activity of 4H-Thieno[3,2-c]Chromene Derivatives. Chem Heterocycl Comp 50, 1712–1718 (2015). https://doi.org/10.1007/s10593-015-1642-4
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DOI: https://doi.org/10.1007/s10593-015-1642-4