1-Aryl-substituted tetrahydrothieno[3,2-с]pyridines easily undergo domino reactions with activated alkynes, giving good yields of the corresponding tetrahydrothieno[2,3-d]azocines. The reactions of 1-methyl-substituted tetrahydrothieno[3,2-с]pyridine were more complicated.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1451-1458, September, 2014.
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Voskressensky, L.G., Borisova, T.N., Chervyakova, T.M. et al. The First Example of 4,7,8,9-Tetrahydrothieno-[2,3-d]Azocine Synthesis by Domino Reaction of 4-ARYL-4,5,6,7-Tetrahydrothieno[3,2-c]Pyridines with Activated Alkynes. Chem Heterocycl Comp 50, 1338–1345 (2014). https://doi.org/10.1007/s10593-014-1597-x
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DOI: https://doi.org/10.1007/s10593-014-1597-x