An efficient method has been proposed for the preparation of a series of 3-O-acyl derivatives of naloxone. The features of the steric structure and NMR spectra are discussed. Pharmaceutical investigation has shown the promise within the synthesized compounds of creating opiate receptor antagonist compounds with prolonged action.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 519–534, April, 2009.
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Ukrainets, I.V., Tkach, A.A., Gorokhova, O.V. et al. Studies of 3-O-acyl derivatives of naloxone as its potential prodrugs. Chem Heterocycl Comp 45, 405–416 (2009). https://doi.org/10.1007/s10593-009-0278-7
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DOI: https://doi.org/10.1007/s10593-009-0278-7