Abstract
A significant amount of evidence from the past few years has shown that Sirtuin 1 (SIRT1), a histone deacetylase dinucleotide of nicotinamide adenine dinucleotide (NAD+) is closely related to the cerebral ischemia. Several potential neuroprotective strategies like resveratrol, ischemia preconditioning, and caloric restriction exert their neuroprotection effects through SIRT1-related signaling pathway. However, the potential mechanisms and neuroprotection of SIRT1 in the process of cerebral ischemia injury development and recovery have not been systematically elaborated. This review summarized the the deacetylase activity and distribution of SIRT1 as well as analyzed the roles of SIRT1 in astrocytes, microglia, neurons, and brain microvascular endothelial cells (BMECs), and the molecular mechanisms of SIRT1 in cerebral ischemia, providing a theoretical basis for exploration of new therapeutic target in future.
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Abbreviations
- SIRT1:
-
Sirtuin 1
- NAD+ :
-
Nicotinamide adenine dinucleotide
- ATP:
-
Adenosine-triphosphate
- CNS:
-
Central nervous system
- ROS:
-
Reactive oxygen species
- MDA:
-
Malondialdehyde
- SOD:
-
Superoxide dismutase
- GSH-Px:
-
Glutathione peroxidase
- Trp:
-
Tryptophan
- QA:
-
Quinolinic acid
- NAMN:
-
Nicotinic acid mononucleotide
- NAAD:
-
Nicotinic acid adenine dinucleotide
- NMNAT:
-
Nicotinamide mononucleotide adenylyl transferase
- NMN:
-
Nicotinamide mononucleotide
- FOXO:
-
Fork head box O
- MnSOD:
-
Manganese superoxide dismutase
- MCAO:
-
Middle cerebral artery occlusion
- OGD/R:
-
Oxygen–glucose deprivation/reoxygenation
- PGC1α:
-
Peroxisome proliferator-activated receptor coactivator 1α
- NF-κB:
-
Nuclear factor-kappa B
- AMPK:
-
Adenosine monophosphate-activated protein kinase
- mTOR:
-
Mammalian target of rapamycin
- PPARγ:
-
Peroxisome proliferator-activated receptor
- VEGF:
-
Vascular endothelial growth factor
- HIF-1α:
-
Hypoxia-inducible factor-1α
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Acknowledgements
This work was supported by National Natural Science Foundation of China (No. 81873226); Zhejiang Provincial Natural Science Foundation (No. LZ18H270001); National Major Scientific and Technological Special Project for “Significant New Drugs Development” (No. 2019ZX09301101); Zhejiang Provincial Science and Technology Innovation Leading Talent Project of “Ten Thousand Talents Plan” (2019).
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YF had the idea for the article, YF and YH prepared and revised the manuscript. HW, CS, and LJ were responsible for literature collection and data analysis.
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Fangma, Y., Wan, H., Shao, C. et al. Research Progress on the Role of Sirtuin 1 in Cerebral Ischemia. Cell Mol Neurobiol 43, 1769–1783 (2023). https://doi.org/10.1007/s10571-022-01288-3
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DOI: https://doi.org/10.1007/s10571-022-01288-3