Mitochondrial quality control in cardiac ischemia/reperfusion injury: new insights into mechanisms and implications

Bai, Yang; Wu, Jinjing; Yang, Zhenyu; Wang, Xu’an; Zhang, Dongni; Ma, Jun

doi:10.1007/s10565-022-09716-2

Mitochondrial quality control in cardiac ischemia/reperfusion injury: new insights into mechanisms and implications

Review
Published: 11 August 2022

Volume 39, pages 33–51, (2023)
Cite this article

Cell Biology and Toxicology Aims and scope Submit manuscript

Yang Bai¹,
Jinjing Wu¹,
Zhenyu Yang²,
Xu’an Wang¹,
Dongni Zhang¹ &
…
Jun Ma¹

2225 Accesses
11 Citations
Explore all metrics

Abstract

The current effective method for the treatment of myocardial infarction is timely restoration of the blood supply to the ischemic area of the heart. Although reperfusion is essential for reestablishing oxygen and nutrient supplies, it often leads to additional myocardial damage, creating an important clinical dilemma. Reports from long-term studies have confirmed that mitochondrial damage is the critical mechanism in cardiac ischemia/reperfusion (I/R) injury. Mitochondria are dynamic and possess a quality control system that targets mitochondrial quantity and quality by modifying mitochondrial fusion, fission, mitophagy, and biogenesis and protein homeostasis to maintain a healthy mitochondrial network. The system of mitochondrial quality control involves complex molecular machinery that is highly interconnected and associated with pathological changes such as oxidative stress, calcium overload, and endoplasmic reticulum (ER) stress. Because of the critical role of the mitochondrial quality control systems, many reports have suggested that defects in this system are among the molecular mechanisms underlying myocardial reperfusion injury. In this review, we briefly summarize the important role of the mitochondrial quality control in cardiomyocyte function and focus on the current understanding of the regulatory mechanisms and molecular pathways involved in mitochondrial quality control in cardiac I/R damage.

Graphical abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Mitophagy as a mitochondrial quality control mechanism in myocardial ischemic stress: from bench to bedside

Article 24 April 2023

Tong Fu, Yanchun Ma, … Ying Tong

Targeting mitochondrial shape: at the heart of cardioprotection

Article Open access 13 November 2023

Sauri Hernandez-Resendiz, Aishwarya Prakash, … Derek J. Hausenloy

Mitochondrial Ca2+ regulation in the etiology of heart failure: physiological and pathophysiological implications

Article 21 July 2020

Hai-xia Xu, Su-mei Cui, … Jun Ren

Data availability

Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

References

Adaniya SM, O-uchi J, Cypress MW, Kusakari Y, Jhun BS. Posttranslational modifications of mitochondrial fission and fusion proteins in cardiac physiology and pathophysiology. Am J Physiol Cell Physiol. 2019;C316:C583–604. https://doi.org/10.1152/ajpcell.00523.2018.
Article CAS Google Scholar
Akimoto T, Pohnert SC, Li P, Zhang M, Gumbs C, Rosenberg PB, et al. Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. J Biol Chem. 2005;280:19587–93. https://doi.org/10.1074/jbc.M408862200.
Article CAS PubMed Google Scholar
Anzell AR, Maizy R, Przyklenk K, Sanderson TH. Mitochondrial quality control and disease: insights into ischemia-reperfusion injury. Mol Neurobiol. 2018;55:2547–64. https://doi.org/10.1007/s12035-017-0503-9.
Article CAS PubMed Google Scholar
Baetz D, Regula KM, Ens K, Shaw J, Kothari S, Yurkova N, et al. Nuclear factor-kappaB-mediated cell survival involves transcriptional silencing of the mitochondrial death gene BNIP3 in ventricular myocytes. Circulation. 2005;112:3777–85. https://doi.org/10.1161/circulationaha.105.573899.
Article CAS PubMed Google Scholar
Bai Y, Yang Y, Gao Y, Lin D, Wang Z, Ma J. Melatonin postconditioning ameliorates anoxia/reoxygenation injury by regulating mitophagy and mitochondrial dynamics in a SIRT3-dependent manner. Eur J Pharmacol. 2021;904: 174157. https://doi.org/10.1016/j.ejphar.2021.174157.
Article CAS PubMed Google Scholar
Bi W, Jia J, Pang R, Nie C, Han J, Ding Z, et al. Thyroid hormone postconditioning protects hearts from ischemia/reperfusion through reinforcing mitophagy. Biomed Pharmacother. 2019;118: 109220. https://doi.org/10.1016/j.biopha.2019.109220.
Article CAS PubMed Google Scholar
Bian X, Xu J, Zhao H, Zheng Q, Xiao X, Ma X, et al. Zinc-induced SUMOylation of dynamin-related protein 1 protects the heart against ischemia-reperfusion injury. Oxid Med Cell Longev. 2019;2019:1232146. https://doi.org/10.1155/2019/1232146.
Article CAS PubMed PubMed Central Google Scholar
Billia F, Hauck L, Konecny F, Rao V, Shen J, Mak TW. PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function. Proc Natl Acad Sci U S A. 2011;108:9572–7. https://doi.org/10.1073/pnas.1106291108.
Article PubMed PubMed Central Google Scholar
Brand CS, Tan VP, Brown JH, Miyamoto S. RhoA regulates Drp1 mediated mitochondrial fission through ROCK to protect cardiomyocytes. Cell Signal. 2018;50:48–57. https://doi.org/10.1016/j.cellsig.2018.06.012.
Article CAS PubMed PubMed Central Google Scholar
Burke N, Hall AR, Hausenloy DJ. OPA1 in cardiovascular health and disease. Curr Drug Targets. 2015;16:912–20. https://doi.org/10.2174/1389450116666150102113648.
Article CAS PubMed Google Scholar
Cao S, Sun Y, Wang W, Wang B, Zhang Q, Pan C, et al. Poly (ADP-ribose) polymerase inhibition protects against myocardial ischaemia/reperfusion injury via suppressing mitophagy. J Cell Mol Med. 2019;23:6897–906. https://doi.org/10.1111/jcmm.14573.
Article CAS PubMed PubMed Central Google Scholar
Cassidy-Stone A, Chipuk JE, Ingerman E, Song C, Yoo C, Kuwana T, et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell. 2008;14:193–204. https://doi.org/10.1016/j.devcel.2007.11.019.
Article CAS PubMed PubMed Central Google Scholar
Chen Z, Liu L, Cheng Q, Li Y, Wu H, Zhang W, et al. Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy. EMBO Rep. 2017; 18: 495–509. https://doi.org/10.15252/embr.201643309.
Chen L, Gong Q, Stice JP, Knowlton AA. Mitochondrial OPA1, apoptosis, and heart failure. Cardiovasc Res. 2009;84:91–9. https://doi.org/10.1093/cvr/cvp181.
Article CAS PubMed PubMed Central Google Scholar
Chen L, Chen XY, Wang QL, Yang SJ, Zhou H, Ding LS, et al. Astragaloside IV Derivative (LS-102) alleviated myocardial ischemia reperfusion injury by inhibiting Drp1(Ser616) phosphorylation-mediated mitochondrial fission. Front Pharmacol. 2020;11:1083. https://doi.org/10.3389/fphar.2020.01083.
Article CAS PubMed PubMed Central Google Scholar
Chen Y, Dorn GW 2nd. PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science. 2013;340:471–5. https://doi.org/10.1126/science.1231031.
Article CAS PubMed PubMed Central Google Scholar
Chen L, Liu T, Tran A, Lu X, Tomilov AA, Davies V, et al. OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. J Am Heart Assoc. 2012;1: e003012. https://doi.org/10.1161/jaha.112.003012.
Article PubMed PubMed Central Google Scholar
Chen G, Han Z, Feng D, Chen Y, Chen L, Wu H, et al. A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy. Mol Cell. 2014;54:362–77. https://doi.org/10.1016/j.molcel.2014.02.034.
Article CAS PubMed Google Scholar
Cogliati S, Frezza C, Soriano ME, Varanita T, Quintana-Cabrera R, Corrado M, et al. Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency. Cell. 2013;155:160–71. https://doi.org/10.1016/j.cell.2013.08.032.
Article CAS PubMed PubMed Central Google Scholar
Czubryt MP, McAnally J, Fishman GI, Olson EN. Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) and mitochondrial function by MEF2 and HDAC5. Proc Natl Acad Sci USA. 2003;100:1711–6. https://doi.org/10.1073/pnas.0337639100.
Article CAS PubMed PubMed Central Google Scholar
Datta Chaudhuri R, Banik A, Mandal B, Sarkar S. Cardiac-specific overexpression of HIF-1α during acute myocardial infarction ameliorates cardiomyocyte apoptosis via differential regulation of hypoxia-inducible pro-apoptotic and anti-oxidative genes. Biochem Biophys Res Commun. 2021;537:100–8. https://doi.org/10.1016/j.bbrc.2020.12.084.
Article CAS PubMed Google Scholar
Deng P, Haynes CM. Mitochondrial dysfunction in cancer: potential roles of ATF5 and the mitochondrial UPR. Semin Cancer Biol. 2017;47:43–9. https://doi.org/10.1016/j.semcancer.2017.05.002.
Article CAS PubMed PubMed Central Google Scholar
Dhingra R, Margulets V, Chowdhury SR, Thliveris J, Jassal D, Fernyhough P, et al. Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling. Proc Natl Acad Sci USA. 2014;111:E5537–44. https://doi.org/10.1073/pnas.1414665111.
Article CAS PubMed PubMed Central Google Scholar
Din S, Mason M, Völkers M, Johnson B, Cottage CT, Wang Z, et al. Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation. Proc Natl Acad Sci USA. 2013;110:5969–74. https://doi.org/10.1073/pnas.1213294110.
Article CAS PubMed PubMed Central Google Scholar
Ding Q, Qi Y, Tsang SY. Mitochondrial biogenesis, mitochondrial dynamics, and mitophagy in the maturation of cardiomyocytes. Cells. 2021;10. https://doi.org/10.3390/cells10092463.
Dorn GW 2nd. Parkin-dependent mitophagy in the heart. J Mol Cell Cardiol. 2016;95:42–9. https://doi.org/10.1016/j.yjmcc.2015.11.023.
Article CAS PubMed Google Scholar
Fernandez-Marcos PJ, Auwerx J. Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis. Am J Clin Nutr. 2011;93:884s-s890. https://doi.org/10.3945/ajcn.110.001917.
Article CAS PubMed PubMed Central Google Scholar
Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LHM, Bechara LRG, et al. A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. Nat Commun. 2019;10:329. https://doi.org/10.1038/s41467-018-08276-6.
Article CAS PubMed PubMed Central Google Scholar
Gao L, Zhao Y, He J, Yan Y, Xu L, Lin N, et al. The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury. J Genet Genomics. 2018;45:125–35. https://doi.org/10.1016/j.jgg.2017.12.002.
Article PubMed Google Scholar
Gegg ME, Cooper JM, Chau KY, Rojo M, Schapira AH, Taanman JW. Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet. 2010;19:4861–70. https://doi.org/10.1093/hmg/ddq419.
Article CAS PubMed PubMed Central Google Scholar
Geisler S, Holmström KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ, et al. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol. 2010;12:119–31. https://doi.org/10.1038/ncb2012.
Article CAS PubMed Google Scholar
Griffiths EJ, Halestrap AP. Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion. Biochem J. 1995;307(Pt 1):93–8. https://doi.org/10.1042/bj3070093.
Article CAS PubMed PubMed Central Google Scholar
Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, et al. Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway. Nature. 2020;579:427–32. https://doi.org/10.1038/s41586-020-2078-2.
Article CAS PubMed PubMed Central Google Scholar
Gustafsson AB. Bnip3 as a dual regulator of mitochondrial turnover and cell death in the myocardium. Pediatr Cardiol. 2011;32:267–74. https://doi.org/10.1007/s00246-010-9876-5.
Article PubMed PubMed Central Google Scholar
Hall AR, Burke N, Dongworth RK, Kalkhoran SB, Dyson A, Vicencio JM, et al. Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction. Cell Death Dis. 2016;7: e2238. https://doi.org/10.1038/cddis.2016.139.
Article CAS PubMed PubMed Central Google Scholar
Hernandez-Resendiz S, Prunier F, Girao H, Dorn G, Hausenloy DJ. Targeting mitochondrial fusion and fission proteins for cardioprotection. J Cell Mol Med. 2020;24:6571–85. https://doi.org/10.1111/jcmm.15384.
Article PubMed PubMed Central Google Scholar
Huang C, Andres AM, Ratliff EP, Hernandez G, Lee P, Gottlieb RA. Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1. PLoS ONE. 2011;6: e20975. https://doi.org/10.1371/journal.pone.0020975.
Article CAS PubMed PubMed Central Google Scholar
Huang J, Li R, Wang C. The role of mitochondrial quality control in cardiac ischemia/reperfusion injury. Oxid Med Cell Longev. 2021a;2021:5543452. https://doi.org/10.1155/2021/5543452.
Article CAS PubMed PubMed Central Google Scholar
Huang Q, Su H, Qi B, Wang Y, Yan K, Wang X, et al. A SIRT1 activator, ginsenoside Rc, promotes energy metabolism in cardiomyocytes and neurons. J Am Chem Soc. 2021b;143:1416–27. https://doi.org/10.1021/jacs.0c10836.
Article CAS PubMed Google Scholar
Ikeda Y, Shirakabe A, Maejima Y, Zhai P, Sciarretta S, Toli J, et al. Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress. Circ Res. 2015;116:264–78. https://doi.org/10.1161/circresaha.116.303356.
Article CAS PubMed Google Scholar
Ishihara N, Fujita Y, Oka T, Mihara K. Regulation of mitochondrial morphology through proteolytic cleavage of OPA1. Embo J. 2006;25:2966–77. https://doi.org/10.1038/sj.emboj.7601184.
Article CAS PubMed PubMed Central Google Scholar
Jäger S, Handschin C, St-Pierre J, Spiegelman BM. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci USA. 2007;104:12017–22. https://doi.org/10.1073/pnas.0705070104.
Article CAS PubMed PubMed Central Google Scholar
Jang S, Javadov S. OPA1 regulates respiratory supercomplexes assembly: the role of mitochondrial swelling. Mitochondrion. 2020;51:30–9. https://doi.org/10.1016/j.mito.2019.11.006.
Article CAS PubMed Google Scholar
Javadov S, Rajapurohitam V, Kilić A, Hunter JC, Zeidan A, Said Faruq N, et al. Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition. Basic Res Cardiol. 2011;106:99–109. https://doi.org/10.1007/s00395-010-0122-3.
Article CAS PubMed Google Scholar
Jiang D, Cui H, Xie N, Banerjee S, Liu RM, Dai H, et al. ATF4 mediates mitochondrial unfolded protein response in alveolar epithelial cells. Am J Respir Cell Mol Biol. 2020;63:478–89. https://doi.org/10.1165/rcmb.2020-0107OC.
Article CAS PubMed PubMed Central Google Scholar
Jiang X, Jiang H, Shen Z, Wang X. Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis. Proc Natl Acad Sci USA. 2014;111:14782–7. https://doi.org/10.1073/pnas.1417253111.
Article CAS PubMed PubMed Central Google Scholar
Jin Q, Li R, Hu N, Xin T, Zhu P, Hu S, et al. DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways. Redox Biol. 2018;14:576–87. https://doi.org/10.1016/j.redox.2017.11.004.
Article CAS PubMed Google Scholar
Jornayvaz FR, Shulman GI. Regulation of mitochondrial biogenesis. Essays Biochem. 2010;47:69–84. https://doi.org/10.1042/bse0470069.
Article CAS PubMed Google Scholar
Kamga Pride C, Mo L, Quesnelle K, Dagda RK, Murillo D, Geary L, et al. Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia/reperfusion. Cardiovasc Res. 2014;101:57–68. https://doi.org/10.1093/cvr/cvt224.
Article CAS PubMed Google Scholar
Kang D, Kim SH, Hamasaki N. Mitochondrial transcription factor A (TFAM): roles in maintenance of mtDNA and cellular functions. Mitochondrion. 2007;7:39–44. https://doi.org/10.1016/j.mito.2006.11.017.
Article CAS PubMed Google Scholar
Korobova F, Ramabhadran V, Higgs HN. An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2. Science. 2013;339:464–7. https://doi.org/10.1126/science.1228360.
Article CAS PubMed Google Scholar
Kuang Y, Ma K, Zhou C, Ding P, Zhu Y, Chen Q, et al. Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy. Autophagy. 2016;12:2363–73. https://doi.org/10.1080/15548627.2016.1238552.
Article CAS PubMed PubMed Central Google Scholar
Kubli DA, Quinsay MN, Huang C, Lee Y, Gustafsson AB. Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion. Am J Physiol Heart Circ Physiol. 2008;295:H2025–31. https://doi.org/10.1152/ajpheart.00552.2008.
Article CAS PubMed PubMed Central Google Scholar
Kubli DA, Zhang X, Lee Y, Hanna RA, Quinsay MN, Nguyen CK, et al. Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction. J Biol Chem. 2013;288:915–26. https://doi.org/10.1074/jbc.M112.411363.
Article CAS PubMed Google Scholar
Kulek AR, Anzell A, Wider JM, Sanderson TH, Przyklenk K. Mitochondrial quality control: role in cardiac models of lethal ischemia-reperfusion injury. Cells. 2020; 9. https://doi.org/10.3390/cells9010214.
Landes T, Martinou JC. Mitochondrial outer membrane permeabilization during apoptosis: the role of mitochondrial fission. Biochim Biophys Acta. 2011;1813:540–5. https://doi.org/10.1016/j.bbamcr.2011.01.021.
Article CAS PubMed Google Scholar
Le Page S, Niro M, Fauconnier J, Cellier L, Tamareille S, Gharib A, et al. Increase in cardiac ischemia-reperfusion injuries in Opa1+/- mouse model. PLoS ONE. 2016;11: e0164066. https://doi.org/10.1371/journal.pone.0164066.
Article CAS PubMed PubMed Central Google Scholar
Lee H, Smith SB, Sheu SS, Yoon Y. The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress. J Biol Chem. 2020;295:6543–60. https://doi.org/10.1074/jbc.RA119.010983.
Article CAS PubMed PubMed Central Google Scholar
Lee Y, Lee HY, Hanna RA, Gustafsson ÅB. Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2011;301:H1924–31. https://doi.org/10.1152/ajpheart.00368.2011.
Article CAS PubMed PubMed Central Google Scholar
Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, et al. PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol. 2005;3: e101. https://doi.org/10.1371/journal.pbio.0030101.
Article CAS PubMed PubMed Central Google Scholar
Li F, Li D, Tang S, Liu J, Yan J, Chen H, et al. Quercetin protects H9c2 cardiomyocytes against oxygen-glucose deprivation/reoxygenation-induced oxidative stress and mitochondrial apoptosis by regulating the ERK1/2/DRP1 signaling pathway. Evid Based Complement Alternat Med. 2021;2021:7522175. https://doi.org/10.1155/2021/7522175.
Article PubMed PubMed Central Google Scholar
Li Y, Liu X. Novel insights into the role of mitochondrial fusion and fission in cardiomyocyte apoptosis induced by ischemia/reperfusion. J Cell Physiol. 2018;233:5589–97. https://doi.org/10.1002/jcp.26522.
Article CAS PubMed Google Scholar
Li E, Li X, Huang J, Xu C, Liang Q, Ren K, et al. BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy. Protein Cell. 2020;11:661–79. https://doi.org/10.1007/s13238-020-00713-x.
Article CAS PubMed PubMed Central Google Scholar
Litonin D, Sologub M, Shi Y, Savkina M, Anikin M, Falkenberg M, et al. Human mitochondrial transcription revisited: only TFAM and TFB2M are required for transcription of the mitochondrial genes in vitro. J Biol Chem. 2010;285:18129–33. https://doi.org/10.1074/jbc.C110.128918.
Article CAS PubMed PubMed Central Google Scholar
Liu L, Feng D, Chen G, Chen M, Zheng Q, Song P, et al. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat Cell Biol. 2012;14:177–85. https://doi.org/10.1038/ncb2422.
Article CAS PubMed Google Scholar
Liu L, Li Y, Wang J, Zhang D, Wu H, Li W, et al. Mitophagy receptor FUNDC1 is regulated by PGC-1α/NRF1 to fine tune mitochondrial homeostasis. EMBO Rep. 2021; 22: e50629. https://doi.org/10.15252/embr.202050629.
Lu YT, Li LZ, Yang YL, Yin X, Liu Q, Zhang L, et al. Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling. Cell Death Dis. 2018;9:672. https://doi.org/10.1038/s41419-018-0708-5.
Article CAS PubMed PubMed Central Google Scholar
Ma X, Godar RJ, Liu H, Diwan A. Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death. Autophagy. 2012;8:297–309. https://doi.org/10.4161/auto.18658.
Article CAS PubMed PubMed Central Google Scholar
Makino A, Suarez J, Gawlowski T, Han W, Wang H, Scott BT, et al. Regulation of mitochondrial morphology and function by O-GlcNAcylation in neonatal cardiac myocytes. Am J Physiol Regul Integr Comp Physiol. 2011;300:R1296–302. https://doi.org/10.1152/ajpregu.00437.2010.
Article CAS PubMed PubMed Central Google Scholar
Mao S, Tian S, Luo X, Zhou M, Cao Z, Li J. Overexpression of PLK1 relieved the myocardial ischemia-reperfusion injury of rats through inducing the mitophagy and regulating the p-AMPK/FUNDC1 axis. Bioengineered. 2021;12:2676–87. https://doi.org/10.1080/21655979.2021.1938500.
Article CAS PubMed PubMed Central Google Scholar
Marinković M, Šprung M, Novak I. Dimerization of mitophagy receptor BNIP3L/NIX is essential for recruitment of autophagic machinery. Autophagy. 2021;17:1232–43. https://doi.org/10.1080/15548627.2020.1755120.
Article CAS PubMed Google Scholar
Melber A, Haynes CM. UPR(mt) regulation and output: a stress response mediated by mitochondrial-nuclear communication. Cell Res. 2018;28:281–95. https://doi.org/10.1038/cr.2018.16.
Article CAS PubMed PubMed Central Google Scholar
Mishra P, Chan DC. Metabolic regulation of mitochondrial dynamics. J Cell Biol. 2016;212:379–87. https://doi.org/10.1083/jcb.201511036.
Article CAS PubMed PubMed Central Google Scholar
Morio A, Tsutsumi R, Kondo T, Miyoshi H, Kato T, Narasaki S, et al. Leucine induces cardioprotection in vitro by promoting mitochondrial function via mTOR and Opa-1 signaling. Nutr Metab Cardiovasc Dis. 2021;31:2979–86. https://doi.org/10.1016/j.numecd.2021.06.025.
Article CAS PubMed Google Scholar
Münch C, Harper JW. Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation. Nature. 2016;534:710–3. https://doi.org/10.1038/nature18302.
Article CAS PubMed PubMed Central Google Scholar
Nan J, Nan C, Ye J, Qian L, Geng Y, Xing D, et al. EGCG protects cardiomyocytes against hypoxia-reperfusion injury through inhibition of OMA1 activation. J Cell Sci. 2019; 132. https://doi.org/10.1242/jcs.220871.
Naya FJ, Black BL, Wu H, Bassel-Duby R, Richardson JA, Hill JA, et al. Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor. Nat Med. 2002;8:1303–9. https://doi.org/10.1038/nm789.
Article CAS PubMed Google Scholar
Olmedo I, Pino G, Riquelme JA, Aranguiz P, Díaz MC, López-Crisosto C, et al. Inhibition of the proteasome preserves Mitofusin-2 and mitochondrial integrity, protecting cardiomyocytes during ischemia-reperfusion injury. Biochim Biophys Acta Mol Basis Dis. 2020;1866: 165659. https://doi.org/10.1016/j.bbadis.2019.165659.
Article CAS PubMed Google Scholar
Ong SB, Subrayan S, Lim SY, Yellon DM, Davidson SM, Hausenloy DJ. Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury. Circulation. 2010;121:2012–22. https://doi.org/10.1161/circulationaha.109.906610.
Article CAS PubMed Google Scholar
Pakos-Zebrucka K, Koryga I, Mnich K, Ljujic M, Samali A, Gorman AM. The integrated stress response. EMBO Rep. 2016; 17: 1374–95. https://doi.org/10.15252/embr.201642195.
Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 2005;122:927–39. https://doi.org/10.1016/j.cell.2005.07.002.
Article CAS PubMed Google Scholar
Pyakurel A, Savoia C, Hess D, Scorrano L. Extracellular regulated kinase phosphorylates mitofusin 1 to control mitochondrial morphology and apoptosis. Mol Cell. 2015;58:244–54. https://doi.org/10.1016/j.molcel.2015.02.021.
Article CAS PubMed PubMed Central Google Scholar
Quinsay MN, Lee Y, Rikka S, Sayen MR, Molkentin JD, Gottlieb RA, et al. Bnip3 mediates permeabilization of mitochondria and release of cytochrome c via a novel mechanism. J Mol Cell Cardiol. 2010;48:1146–56. https://doi.org/10.1016/j.yjmcc.2009.12.004.
Article CAS PubMed Google Scholar
Rikka S, Quinsay MN, Thomas RL, Kubli DA, Zhang X, Murphy AN, et al. Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover. Cell Death Differ. 2011;18:721–31. https://doi.org/10.1038/cdd.2010.146.
Article CAS PubMed Google Scholar
Ristevski S, O’Leary DA, Thornell AP, Owen MJ, Kola I, Hertzog PJ. The ETS transcription factor GABPalpha is essential for early embryogenesis. Mol Cell Biol. 2004;24:5844–9. https://doi.org/10.1128/mcb.24.13.5844-5849.2004.
Article CAS PubMed PubMed Central Google Scholar
Rodríguez-Graciani KM, Chapa-Dubocq XR, MacMillan-Crow LA, Javadov S. Association between L-OPA1 cleavage and cardiac dysfunction during ischemia-reperfusion injury in rats. Cell Physiol Biochem. 2020; 54: 1101–14. https://doi.org/10.33594/000000303.
Rogov VV, Suzuki H, Marinković M, Lang V, Kato R, Kawasaki M, et al. Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins. Sci Rep. 2017;7:1131. https://doi.org/10.1038/s41598-017-01258-6.
Article CAS PubMed PubMed Central Google Scholar
Sakamoto T, Matsuura TR, Wan S, Ryba DM, Kim JU, Won KJ, et al. A critical role for estrogen-related receptor signaling in cardiac maturation. Circ Res. 2020;126:1685–702. https://doi.org/10.1161/circresaha.119.316100.
Article CAS PubMed PubMed Central Google Scholar
Samant SA, Zhang HJ, Hong Z, Pillai VB, Sundaresan NR, Wolfgeher D, et al. SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress. Mol Cell Biol. 2014;34:807–19. https://doi.org/10.1128/mcb.01483-13.
Article PubMed PubMed Central Google Scholar
Sharp WW, Fang YH, Han M, Zhang HJ, Hong Z, Banathy A, et al. Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission. FASEB J. 2014;28:316–26. https://doi.org/10.1096/fj.12-226225.
Article CAS PubMed PubMed Central Google Scholar
She L, Tu H, Zhang YZ, Tang LJ, Li NS, Ma QL, et al. Inhibition of phosphoglycerate mutase 5 reduces necroptosis in rat hearts following ischemia/reperfusion through suppression of dynamin-related protein 1. Cardiovasc Drugs Ther. 2019;33:13–23. https://doi.org/10.1007/s10557-018-06848-8.
Article CAS PubMed Google Scholar
Shi X, Li Y, Wang Y, Ding T, Zhang X, Wu N. Pharmacological postconditioning with sappanone A ameliorates myocardial ischemia reperfusion injury and mitochondrial dysfunction via AMPK-mediated mitochondrial quality control. Toxicol Appl Pharmacol. 2021;427: 115668. https://doi.org/10.1016/j.taap.2021.115668.
Article CAS PubMed Google Scholar
Shimizu Y, Lambert JP, Nicholson CK, Kim JJ, Wolfson DW, Cho HC, et al. DJ-1 protects the heart against ischemia-reperfusion injury by regulating mitochondrial fission. J Mol Cell Cardiol. 2016;97:56–66. https://doi.org/10.1016/j.yjmcc.2016.04.008.
Article CAS PubMed PubMed Central Google Scholar
Siddall HK, Yellon DM, Ong SB, Mukherjee UA, Burke N, Hall AR, et al. Loss of PINK1 increases the heart’s vulnerability to ischemia-reperfusion injury. PLoS ONE. 2013;8: e62400. https://doi.org/10.1371/journal.pone.0062400.
Article CAS PubMed PubMed Central Google Scholar
Smyrnias I. The mitochondrial unfolded protein response and its diverse roles in cellular stress. Int J Biochem Cell Biol. 2021;133: 105934. https://doi.org/10.1016/j.biocel.2021.105934.
Article CAS PubMed Google Scholar
Song X, Li T. Ripk3 mediates cardiomyocyte necrosis through targeting mitochondria and the JNK-Bnip3 pathway under hypoxia-reoxygenation injury. J Recept Signal Transduct Res. 2019;39:331–40. https://doi.org/10.1080/10799893.2019.1676259.
Article CAS PubMed Google Scholar
Song J, Herrmann JM, Becker T. Quality control of the mitochondrial proteome. Nat Rev Mol Cell Biol. 2021;22:54–70. https://doi.org/10.1038/s41580-020-00300-2.
Article CAS PubMed Google Scholar
Song M, Gong G, Burelle Y, Gustafsson ÅB, Kitsis RN, Matkovich SJ, et al. Interdependence of Parkin-mediated mitophagy and mitochondrial fission in adult mouse hearts. Circ Res. 2015;117:346–51. https://doi.org/10.1161/circresaha.117.306859.
Article CAS PubMed PubMed Central Google Scholar
Stanley WC. Myocardial energy metabolism during ischemia and the mechanisms of metabolic therapies. J Cardiovasc Pharmacol Ther. 2004;9(Suppl 1):S31-45. https://doi.org/10.1177/107424840400900104.
Article CAS PubMed Google Scholar
Subramani J, Kundumani-Sridharan V, Das KC. Thioredoxin protects mitochondrial structure, function and biogenesis in myocardial ischemia-reperfusion via redox-dependent activation of AKT-CREB- PGC1α pathway in aged mice. Aging (Albany NY). 2020; 12: 19809–27. https://doi.org/10.18632/aging.104071.
Sun T, Ding W, Xu T, Ao X, Yu T, Li M, et al. Parkin regulates programmed necrosis and myocardial ischemia/reperfusion injury by targeting cyclophilin-D. Antioxid Redox Signal. 2019;31:1177–93. https://doi.org/10.1089/ars.2019.7734.
Article CAS PubMed Google Scholar
Tang Y, Liu J, Long J. Phosphatase and tensin homolog-induced putative kinase 1 and Parkin in diabetic heart: role of mitophagy. J Diabetes Investig. 2015;6:250–5. https://doi.org/10.1111/jdi.12302.
Article CAS PubMed Google Scholar
Tao A, Xu X, Kvietys P, Kao R, Martin C, Rui T. Experimental diabetes mellitus exacerbates ischemia/reperfusion-induced myocardial injury by promoting mitochondrial fission: role of down-regulation of myocardial Sirt1 and subsequent Akt/Drp1 interaction. Int J Biochem Cell Biol. 2018;105:94–103. https://doi.org/10.1016/j.biocel.2018.10.011.
Article CAS PubMed Google Scholar
Tao L, Bei Y, Lin S, Zhang H, Zhou Y, Jiang J, et al. Exercise training protects against acute myocardial infarction via improving myocardial energy metabolism and mitochondrial biogenesis. Cell Physiol Biochem. 2015;37:162–75. https://doi.org/10.1159/000430342.
Article CAS PubMed Google Scholar
Tian F, Zhang Y. Overexpression of SERCA2a alleviates cardiac microvascular ischemic injury by suppressing Mfn2-mediated ER/mitochondrial calcium tethering. Front Cell Dev Biol. 2021;9: 636553. https://doi.org/10.3389/fcell.2021.636553.
Article PubMed PubMed Central Google Scholar
Valle I, Alvarez-Barrientos A, Arza E, Lamas S, Monsalve M. PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells. Cardiovasc Res. 2005;66:562–73. https://doi.org/10.1016/j.cardiores.2005.01.026.
Article CAS PubMed Google Scholar
Vernochet C, Mourier A, Bezy O, Macotela Y, Boucher J, Rardin MJ, et al. Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance. Cell Metab. 2012;16:765–76. https://doi.org/10.1016/j.cmet.2012.10.016.
Article CAS PubMed PubMed Central Google Scholar
Wai T, García-Prieto J, Baker MJ, Merkwirth C, Benit P, Rustin P, et al. Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice. Science. 2015;350:aad0116. https://doi.org/10.1126/science.aad0116.
Article CAS PubMed Google Scholar
Wang S, Zhang F, Zhao G, Cheng Y, Wu T, Wu B, et al. Mitochondrial PKC-ε deficiency promotes I/R-mediated myocardial injury via GSK3β-dependent mitochondrial permeability transition pore opening. J Cell Mol Med. 2017;21:2009–21. https://doi.org/10.1111/jcmm.13121.
Article CAS PubMed PubMed Central Google Scholar
Wang YT, Lim Y, McCall MN, Huang KT, Haynes CM, Nehrke K, et al. Cardioprotection by the mitochondrial unfolded protein response requires ATF5. Am J Physiol Heart Circ Physiol. 2019;317:H472–8. https://doi.org/10.1152/ajpheart.00244.2019.
Article CAS PubMed PubMed Central Google Scholar
Wang L, Qi H, Tang Y, Shen HM. Post-translational modifications of key machinery in the control of mitophagy. Trends Biochem Sci. 2020b;45:58–75. https://doi.org/10.1016/j.tibs.2019.08.002.
Article CAS PubMed Google Scholar
Wang J, Toan S, Zhou H. Mitochondrial quality control in cardiac microvascular ischemia-reperfusion injury: new insights into the mechanisms and therapeutic potentials. Pharmacol Res. 2020a;156: 104771. https://doi.org/10.1016/j.phrs.2020.104771.
Article CAS PubMed Google Scholar
Wang J, Zhou H. Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia-reperfusion injury. Acta Pharm Sin B. 2020;10:1866–79. https://doi.org/10.1016/j.apsb.2020.03.004.
Article CAS PubMed PubMed Central Google Scholar
Wang JX, Jiao JQ, Li Q, Long B, Wang K, Liu JP, et al. miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1. Nat Med. 2011;17:71–8. https://doi.org/10.1038/nm.2282.
Article CAS PubMed Google Scholar
Wu W, Tian W, Hu Z, Chen G, Huang L, Li W, et al. ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy. EMBO Rep. 2014;15:566–75. https://doi.org/10.1002/embr.201438501.
Article CAS PubMed PubMed Central Google Scholar
Wu W, Lin C, Wu K, Jiang L, Wang X, Li W, et al. FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions. EMBO J. 2016; 35: 1368–84. https://doi.org/10.15252/embj.201593102.
Wu S, Lu Q, Wang Q, Ding Y, Ma Z, Mao X, et al. Binding of FUN14 domain containing 1 with inositol 1,4,5-trisphosphate receptor in mitochondria-associated endoplasmic reticulum membranes maintains mitochondrial dynamics and function in hearts in vivo. Circulation. 2017;136:2248–66. https://doi.org/10.1161/circulationaha.117.030235.
Article CAS PubMed PubMed Central Google Scholar
Xiang Q, Wu M, Zhang L, Fu W, Yang J, Zhang B, et al. Gerontoxanthone I and macluraxanthone induce mitophagy and attenuate ischemia/reperfusion injury. Front Pharmacol. 2020;11:452. https://doi.org/10.3389/fphar.2020.00452.
Article CAS PubMed PubMed Central Google Scholar
Yang KC, Ma X, Liu H, Murphy J, Barger PM, Mann DL, et al. Tumor necrosis factor receptor-associated factor 2 mediates mitochondrial autophagy. Circ Heart Fail. 2015;8:175–87. https://doi.org/10.1161/circheartfailure.114.001635.
Article CAS PubMed Google Scholar
Yang J, He J, Ismail M, Tweeten S, Zeng F, Gao L, et al. HDAC inhibition induces autophagy and mitochondrial biogenesis to maintain mitochondrial homeostasis during cardiac ischemia/reperfusion injury. J Mol Cell Cardiol. 2019a;130:36–48. https://doi.org/10.1016/j.yjmcc.2019.03.008.
Article CAS PubMed PubMed Central Google Scholar
Yang M, Linn BS, Zhang Y, Ren J. Mitophagy and mitochondrial integrity in cardiac ischemia-reperfusion injury. Biochim Biophys Acta Mol Basis Dis. 2019b;1865:2293–302. https://doi.org/10.1016/j.bbadis.2019.05.007.
Article CAS PubMed Google Scholar
Yang L, Xie P, Wu J, Yu J, Li X, Ma H, et al. Deferoxamine treatment combined with sevoflurane postconditioning attenuates myocardial ischemia-reperfusion injury by restoring HIF-1/BNIP3-mediated mitochondrial autophagy in GK rats. Front Pharmacol. 2020;11:6. https://doi.org/10.3389/fphar.2020.00006.
Article CAS PubMed PubMed Central Google Scholar
Yurkova N, Shaw J, Blackie K, Weidman D, Jayas R, Flynn B, et al. The cell cycle factor E2F–1 activates Bnip3 and the intrinsic death pathway in ventricular myocytes. Circ Res. 2008;102:472–9. https://doi.org/10.1161/circresaha.107.164731.
Article CAS PubMed Google Scholar
Zaja I, Bai X, Liu Y, Kikuchi C, Dosenovic S, Yan Y, et al. Cdk1, PKCδ and calcineurin-mediated Drp1 pathway contributes to mitochondrial fission-induced cardiomyocyte death. Biochem Biophys Res Commun. 2014;453:710–21. https://doi.org/10.1016/j.bbrc.2014.09.144.
Article CAS PubMed PubMed Central Google Scholar
Zhang W, Ren H, Xu C, Zhu C, Wu H, Liu D, et al. Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury. Elife. 2016; 5. https://doi.org/10.7554/eLife.21407.
Zhang D, Li Y, Heims-Waldron D, Bezzerides V, Guatimosim S, Guo Y, et al. Mitochondrial cardiomyopathy caused by elevated reactive oxygen species and impaired cardiomyocyte proliferation. Circ Res. 2018;122:74–87. https://doi.org/10.1161/circresaha.117.311349.
Article CAS PubMed Google Scholar
Zhang Y, Wang Y, Xu J, Tian F, Hu S, Chen Y, et al. Melatonin attenuates myocardial ischemia-reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK-OPA1 signaling pathways. J Pineal Res. 2019;66: e12542. https://doi.org/10.1111/jpi.12542.
Article CAS PubMed Google Scholar
Zhang B, Tan Y, Zhang Z, Feng P, Ding W, Wang Q, et al. Novel PGC-1α/ATF5 axis partly activates UPR(mt) and mediates cardioprotective role of tetrahydrocurcumin in pathological cardiac hypertrophy. Oxid Med Cell Longev. 2020;2020:9187065. https://doi.org/10.1155/2020/9187065.
Article CAS PubMed PubMed Central Google Scholar
Zhang G, Wang X, Li C, Li Q, An YA, Luo X, et al. Integrated stress response couples mitochondrial protein translation with oxidative stress control. Circulation. 2021;144:1500–15. https://doi.org/10.1161/circulationaha.120.053125.
Article CAS PubMed PubMed Central Google Scholar
Zhao Q, Wang J, Levichkin IV, Stasinopoulos S, Ryan MT, Hoogenraad NJ. A mitochondrial specific stress response in mammalian cells. Embo J. 2002;21:4411–9. https://doi.org/10.1093/emboj/cdf445.
Article CAS PubMed PubMed Central Google Scholar
Zhao T, Huang X, Han L, Wang X, Cheng H, Zhao Y, et al. Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytes. J Biol Chem. 2012;287:23615–25. https://doi.org/10.1074/jbc.M112.379164.
Article CAS PubMed PubMed Central Google Scholar
Zheng X, Zhong T, Ma Y, Wan X, Qin A, Yao B, et al. Bnip3 mediates doxorubicin-induced cardiomyocyte pyroptosis via caspase-3/GSDME. Life Sci. 2020;242: 117186. https://doi.org/10.1016/j.lfs.2019.117186.
Article CAS PubMed Google Scholar
Zhou H, Wang J, Zhu P, Zhu H, Toan S, Hu S, et al. NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α. Basic Res Cardiol. 2018a;113:23. https://doi.org/10.1007/s00395-018-0682-1.
Article CAS PubMed Google Scholar
Zhou H, Zhang Y, Hu S, Shi C, Zhu P, Ma Q, et al. Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis. J Pineal Res. 2017a; 63. https://doi.org/10.1111/jpi.12413.
Zhou H, Zhu P, Guo J, Hu N, Wang S, Li D, et al. Ripk3 induces mitochondrial apoptosis via inhibition of FUNDC1 mitophagy in cardiac IR injury. Redox Biol. 2017b;13:498–507. https://doi.org/10.1016/j.redox.2017.07.007.
Article CAS PubMed PubMed Central Google Scholar
Zhou H, Zhu P, Wang J, Zhu H, Ren J, Chen Y. Pathogenesis of cardiac ischemia reperfusion injury is associated with CK2α-disturbed mitochondrial homeostasis via suppression of FUNDC1-related mitophagy. Cell Death Differ. 2018b;25:1080–93. https://doi.org/10.1038/s41418-018-0086-7.
Article CAS PubMed PubMed Central Google Scholar
Zhou XL, Wu X, Xu QR, Zhu RR, Xu H, Li YY, et al. Notch1 provides myocardial protection by improving mitochondrial quality control. J Cell Physiol. 2019;234:11835–41. https://doi.org/10.1002/jcp.27892.
Article CAS PubMed Google Scholar
Zhu Y, Massen S, Terenzio M, Lang V, Chen-Lindner S, Eils R, et al. Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. J Biol Chem. 2013;288:1099–113. https://doi.org/10.1074/jbc.M112.399345.
Article CAS PubMed Google Scholar
Zhu H, Toan S, Mui D, Zhou H. Mitochondrial quality surveillance as a therapeutic target in myocardial infarction. Acta Physiol (Oxf). 2021b;231: e13590. https://doi.org/10.1111/apha.13590.
Article CAS PubMed Google Scholar
Zhu N, Li J, Li Y, Zhang Y, Du Q, Hao P, et al. Berberine protects against simulated ischemia/reperfusion injury-induced H9C2 cardiomyocytes apoptosis in vitro and myocardial ischemia/reperfusion-induced apoptosis in vivo by regulating the mitophagy-mediated HIF-1α/BNIP3 pathway. Front Pharmacol. 2020;11:367. https://doi.org/10.3389/fphar.2020.00367.
Article CAS PubMed PubMed Central Google Scholar
Zhu H, Tan Y, Du W, Li Y, Toan S, Mui D, et al. Phosphoglycerate mutase 5 exacerbates cardiac ischemia-reperfusion injury through disrupting mitochondrial quality control. Redox Biol. 2021a;38: 101777. https://doi.org/10.1016/j.redox.2020.101777.
Article CAS PubMed Google Scholar
Zhu P, Wan K, Yin M, Hu P, Que Y, Zhou X, et al. RIPK3 induces cardiomyocyte necroptosis via inhibition of AMPK-Parkin-mitophagy in cardiac remodelling after myocardial infarction. Oxid Med Cell Longev. 2021c;2021:6635955. https://doi.org/10.1155/2021/6635955.
Article CAS PubMed PubMed Central Google Scholar

Download references

Funding

This study was supported by grants from the National Natural Science Foundation of China (No. 81871592).

Author information

Authors and Affiliations

Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, No.2 Anzhen Road, Chaoyang District, Beijing, 100029, People’s Republic of China
Yang Bai, Jinjing Wu, Xu’an Wang, Dongni Zhang & Jun Ma
Department of Endocrinology, South China Hospital of Shenzhen University, Shenzhen, People’s Republic of China
Zhenyu Yang

Authors

Yang Bai
View author publications
You can also search for this author in PubMed Google Scholar
Jinjing Wu
View author publications
You can also search for this author in PubMed Google Scholar
Zhenyu Yang
View author publications
You can also search for this author in PubMed Google Scholar
Xu’an Wang
View author publications
You can also search for this author in PubMed Google Scholar
Dongni Zhang
View author publications
You can also search for this author in PubMed Google Scholar
Jun Ma
View author publications
You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jun Ma.

Ethics declarations

Ethics approval

Not applicable.

Consent for publication

All the work reported in the manuscript is original and has not yet been submitted in other journal. Authors agree to transfer the copyright of manuscript to the Applied Biochemistry and Biotechnology Journal upon acceptance for publication.

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Headlights

1. Mitochondrial structure and function are regulated by mitochondrial fission and fusion.

2. New mitochondria are generated via mitochondrial biogenesis.

3. Upon mitochondrial stress, UPR^mt is activated to restore mitochondrial proteomics.

4. Unrepairable mitochondria are removed via the process of mitophagy.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bai, Y., Wu, J., Yang, Z. et al. Mitochondrial quality control in cardiac ischemia/reperfusion injury: new insights into mechanisms and implications. Cell Biol Toxicol 39, 33–51 (2023). https://doi.org/10.1007/s10565-022-09716-2

Download citation

Received: 12 January 2022
Accepted: 07 April 2022
Published: 11 August 2022
Issue Date: February 2023
DOI: https://doi.org/10.1007/s10565-022-09716-2

Keywords

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Mitochondrial quality control in cardiac ischemia/reperfusion injury: new insights into mechanisms and implications