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Functional survey of decellularized tissues transplantation for infertile females

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Abstract

Numbers of women worldwide face infertility, which will have a significant impact on a couple's life. As a result, assisting with the treatment of these individuals is seen as a critical step. Successful births following uterus and ovary donation have been reported in recent. When immunosuppressive drugs are used in patients who receive donated tissues, there are always problems with the drugs' side effects. In recent years, tissue engineering has mainly been successful in treating infertility using decellularization techniques. Engineered uterus and ovary prevent immunological reactions and do not require immunosuppressive drugs. The most important aspect of using decellularized tissue is its proper function after transplantation. These tissues must be able to produce follicles, secrete hormones and cause pregnancy. This study aimed to investigate research on decellularized tissues and transplanted into the female reproductive system. In this study, just tissues that, after transplantation, have the proper function for fertility were investigated.

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Data availability

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

Abbreviations

TE:

Tissue engineering

GP:

Genipin

HHP:

High hydrostatic pressure

PC:

Procyanidins

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Acknowledgements

The authors would like to thank the Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Author information

Authors and Affiliations

  1. Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Mozafar Khazaei, Mohammad Rasool Khazaei & Leila Rezakhani

  2. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran

    Morteza Alizadeh

  3. Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran

    Shima Rahmati

  4. Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Shahid Shiroudi Boulevard – St., 6714869914, Kermanshah, Iran

    Leila Rezakhani

Authors
  1. Mozafar Khazaei
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  2. Mohammad Rasool Khazaei
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  3. Morteza Alizadeh
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  4. Shima Rahmati
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  5. Leila Rezakhani
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Contributions

LR, MKH, and MA drafted the overall concept of this work. LR, MRKH, and SHR. wrote the review with help from MKH and MA. All authors have read, revised, and gave final approval of the submitted version.

Corresponding author

Correspondence to Leila Rezakhani.

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The authors declare that they have no conflict of interest.

Ethical approval

This study was under the approval code of IR.KUMS.REC.1400.162 in Kermanshah University of Medical Sciences, Kermanshah, Iran.

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Khazaei, M., Khazaei, M.R., Alizadeh, M. et al. Functional survey of decellularized tissues transplantation for infertile females. Cell Tissue Bank 23, 407–415 (2022). https://doi.org/10.1007/s10561-021-09979-9

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  • DOI: https://doi.org/10.1007/s10561-021-09979-9

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