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Resveratrol Confers Endothelial Protection in Insulin-Dependent Diabetes Mellitus

Editorial to: "Resveratrol Shows Vasoprotective Effect Reducing Oxidative Stress Without Affecting Metabolic Disturbances in Insulin-dependent Diabetes of Rabbits" by F. Akar et al.

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References

  1. Pendurthi UR, Rao LV. Resveratrol suppresses agonist-induced monocyte adhesion to cultured human endothelial cells. Thromb Res. 2002;106:243–8.

    Article  PubMed  CAS  Google Scholar 

  2. Ungvari Z, Orosz Z, Rivera A, et al. Resveratrol increases vascular oxidative stress resistance. Am J Physiol. 2007;292:H2417–24.

    CAS  Google Scholar 

  3. Wallerath T, Deckert G, Ternes T, et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation. 2002;106:1652–8.

    Article  PubMed  CAS  Google Scholar 

  4. Csiszar A, Labinskyy N, Podlutsky A, et al. Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. Am J Physiol Heart Circ Physiol. 2008;294:H2721–35.

    Article  PubMed  CAS  Google Scholar 

  5. Thirunavukkarasu M, Penumathsa SV, Koneru S, et al. Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase. Free Radic Biol Med. 2007;43:720–9.

    Article  PubMed  CAS  Google Scholar 

  6. Csiszar A, Labinskyy N, Pinto JT, et al. Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol. 2009;297:H13–20.

    Article  PubMed  CAS  Google Scholar 

  7. Zhang H, Zhang J, Ungvari Z, Zhang C. Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress. Arterioscler Thromb Vasc Biol. 2009;29:1164–71.

    Article  PubMed  CAS  Google Scholar 

  8. Ungvari Z, Labinskyy N, Mukhopadhyay P, et al. Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. Am J Physiol Heart Circ Physiol. 2009;297:H1876–81.

    Article  PubMed  CAS  Google Scholar 

  9. Chow SE, Hshu YC, Wang JS, Chen JK. Resveratrol attenuates oxLDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages. J Appl Physiol. 2007;102:1520–7.

    Article  PubMed  CAS  Google Scholar 

  10. Ungvari Z, Bagi Z, Feher A, et al. Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol. 2010;299:H18–24.

    Article  PubMed  CAS  Google Scholar 

  11. Gracia-Sancho J, Villarreal Jr G, Zhang Y, Garcia-Cardena G. Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype. Cardiovasc Res. 2009;85:514–9.

    Article  PubMed  Google Scholar 

  12. Zhang H, Morgan B, Potter BJ, Ma L, Dellsperger KC, Ungvari ZI, Zhang C. Resveratrol Improves Left Ventricular Diastolic Relaxation in Type 2 Diabetes by Inhibiting Oxidative/Nitrative Stress. Am J Physiol Heart Circ Physiol. 2010: in press.

  13. Milne JC, Lambert PD, Schenk S, et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007;450:712–6.

    Article  PubMed  CAS  Google Scholar 

  14. Pearson KJ, Baur JA, Lewis KN, Peshkin L, et al. Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span. Cell Metab. 2008;8:157–68.

    Article  PubMed  CAS  Google Scholar 

  15. Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006;444:337–42.

    Article  PubMed  CAS  Google Scholar 

  16. Palsamy P, Subramanian S. Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats. Biomed Pharmacother. 2008;62:598–605.

    Article  PubMed  CAS  Google Scholar 

  17. Akar F, Pektas MB, Tufan C, et al. Resveratrol Shows Vasoprotective Effect Reducing Oxidative Stress Without Affecting Metabolic Disturbances in Insulin-Dependent Diabetes of Rabbits. Cardiovasc Drugs Ther. 2011;25: this issue

  18. Sulaiman M, Matta MJ, Sunderesan NR, Gupta MP, Periasamy M, Gupta M. Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2010;298:H833–43.

    Article  PubMed  CAS  Google Scholar 

  19. Ou HC, Chou FP, Sheen HM, Lin TM, Yang CH. Huey-Herng Sheu W. Resveratrol, a polyphenolic compound in red wine, protects against oxidized LDL-induced cytotoxicity in endothelial cells. Clin Chim Acta. 2006;364:196–204.

    Article  PubMed  CAS  Google Scholar 

  20. Smith JJ, Kenney RD, Gagne DJ, et al. Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. BMC Syst Biol. 2009;3:31.

    Article  PubMed  Google Scholar 

  21. Orimo M, Minamino T, Miyauchi H, et al. Protective role of SIRT1 in diabetic vascular dysfunction. Arterioscler Thromb Vasc Biol. 2009;29:889–94.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

This work was supported by grants from the American Federation for Aging Research (to AC), the University of Oklahoma College of Medicine Alumni Association (to AC), the American Diabetes Association (to ZU) and the NIH (AT006526 and HL077256).

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Correspondence to Zoltan Ungvari.

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Ungvari, Z., Csiszar, A. Resveratrol Confers Endothelial Protection in Insulin-Dependent Diabetes Mellitus. Cardiovasc Drugs Ther 25, 111–113 (2011). https://doi.org/10.1007/s10557-010-6267-3

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  • DOI: https://doi.org/10.1007/s10557-010-6267-3

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