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Intracranial Hemorrhages Associated with Intravenous Platelet Glycoprotein IIB/IIIA Receptor Inhibitors in the United States

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Summary

Objectives: To determine the rates of intracranial hemorrhages associated with GP IIb/IIIa inhibitors in routine practice.

Background: Rates of intracranial hemorrhages (ICH) among patients treated with platelet glycoprotein (GP) IIb/IIIa inhibitors for coronary interventions and acute coronary syndromes have been studied within clinical trials but not in routine practice.

Methods: We evaluated the rates of ICH in routine practice in United States (US) using national estimates of rates, in-hospital outcomes, and mortality obtained from National Hospital Discharge Survey.

Results: There were 367 294 patients aged 18 years or greater who were treated with platelet GP IIb/IIIa inhibitors between 2000 and 2002 in United States. ICH was observed in 479 (0.13%) of the 367 294 patients with a 100% associated mortality. ICHs related to GP IIb/IIIa inhibitors comprised 0.12% of the total number of ICHs (n=411 621) observed in United States between 2000 and 2002.

Conclusions: ICH related to platelet GPIIb/IIIa inhibitors is uncommon but associated with high mortality.

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References

  1. Vorchheimer DA, Badimon JJ, Fuster V. Platelet glycoprotein IIb/IIIa receptor antagonists in cardiovascular disease. Jama 1999;281(15):1407–1414.

    Article  PubMed  CAS  Google Scholar 

  2. CDER New and Generic Drug Approvals:1998–2004. http://www.fda.gov/cder/approval/.Accessed June 25, 2005; Volume 2005.

  3. Memon MA, Blankenship JC, Wood GC, Frey CM, Menapace FJ. Incidence of intracranial hemorrhage complicating treatment with glycoprotein IIb/IIIa receptor inhibitors: A pooled analysis of major clinical trials. Am J Med 2000;109(3):213–217.

    Article  PubMed  CAS  Google Scholar 

  4. Qureshi AI, Saad M, Zaidat OO, Suarez JI, Alexander MJ, Fareed M, et al. Intracerebral hemorrhages associated with neurointerventional procedures using a combination of antithrombotic agents including abciximab. Stroke 2002;33(7):1916–1919.

    Article  PubMed  CAS  Google Scholar 

  5. Zidane M, Schram MT, Planken EW, Molendijk WH, Rosendaal FR, van der Meer FJ, et al. Frequency of major hemorrhage in patients treated with unfractionated intravenous heparin for deep venous thrombosis or pulmonary embolism: A study in routine clinical practice. Arch Intern Med 2000;160(15):2369–73.

    Article  PubMed  CAS  Google Scholar 

  6. Denison C, Pokras R. Design and operation of the National Hospital Discharge Survey: 1988 redesign. National Center for Health Statistics 2000;1–50.

  7. Haupt B, Kozak L. Estimates from two survey designs: National Hospital Discharage Survey: National Center for Health Statistics. Vital Health Stat 1992;1–75.

  8. National Centre for Health Statistics: International Classification of Diseases 9th Revision, Clinical Modification. Washington, DC: US Public Health Service; 1980.

    Google Scholar 

  9. Mayer SA, Copeland D, Bernardini GL, Boden-Albala B, Lennihan L, Kossoff S, et al. Cost and outcome of mechanical ventilation for life-threatening stroke. Stroke 2000;31(10):2346–2353.

    PubMed  CAS  Google Scholar 

  10. Shah B, Barnwell B, Gayle B. SUDAAN user's manual: software for analysis of correlated data. In. 7.01 ed: Research Triangle Park, NC: Research Triangle Institute; 1996.

    Google Scholar 

  11. Sara B, Roberts K. Medical Advisory Panel Drug Class Review: Glycoprotein (GP) IIb/IIIa Receptor Inhibitors for use in Acute Coronary Syndromes (ACS) & Percutaneous Coronary Intervention (PCI). In: 2004 (11). http://www.vapbm.org/reviews/glycoproteinreview.pdf.

  12. Lenderink T, Boersma E, Ruzyllo W, Widimsky P, Ohman EM, Armstrong PW, et al. Bleeding events with abciximab in acute coronary syndromes without early revascularization: An analysis of GUSTO IV-ACS. Am Heart J 2004;147(5):865–873.

    Article  PubMed  CAS  Google Scholar 

  13. Savonitto S, Armstrong PW, Lincoff AM, Jia G, Sila CA, Booth J, et al. Risk of intracranial haemorrhage with combined fibrinolytic and glycoprotein IIb/IIIa inhibitor therapy in acute myocardial infarction. Dichotomous response as a function of age in the GUSTO V trial. Eur Heart J 2003;24(20):1807–1814.

    CAS  Google Scholar 

  14. Iakovou I, Dangas G, Mintz GS, Mehran R, Lansky AJ, Aymong ED, et al. Comparison of frequency of hemorrhagic stroke in patients <75 years versus > or = 75 years of age among patients receiving glycoprotein IIb/IIIa inhibitors during percutaneous coronary interventions. Am J Cardiol 2004;93(3):346–349.

    Article  PubMed  CAS  Google Scholar 

  15. Fang J, Alderman MH. Trend of stroke hospitalization, United States, 1988–1997. Stroke 2001;32(10):2221–2226.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Zeenat Qureshi Stroke Research Center, University of Medicine and Dentistry of New Jersey, Newark, New Jersey

    Adnan I. Qureshi M.D., M. S. Hussain, Abu Nasar, Jawad F. Kirmani, Afshin A. Divani, Shafiudin Ahmed & M. Fareed K. Suri

  2. Department of Neurology and Neurosciences, UMDNJ, DOC-8100, 90 Bergen Street, Newark, 07103, NJ

    Adnan I. Qureshi M.D.

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  1. Adnan I. Qureshi M.D.
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  2. M. S. Hussain
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  3. Abu Nasar
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  4. Jawad F. Kirmani
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  5. Afshin A. Divani
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  6. Shafiudin Ahmed
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  7. M. Fareed K. Suri
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Correspondence to Adnan I. Qureshi M.D..

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Qureshi, A.I., Hussain, M.S., Nasar, A. et al. Intracranial Hemorrhages Associated with Intravenous Platelet Glycoprotein IIB/IIIA Receptor Inhibitors in the United States. Cardiovasc Drugs Ther 19, 371–373 (2005). https://doi.org/10.1007/s10557-005-4390-3

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  • DOI: https://doi.org/10.1007/s10557-005-4390-3

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