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Stress, inflammation, and eicosanoids: an emerging perspective

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Abstract

Clinical and experimental studies support the notion that adrenergic stimulation and chronic stress affect inflammation, metabolism, and tumor growth. Eicosanoids are also known to heavily influence inflammation while regulating certain stress responses. However, additional work is needed to understand the full extent of interactions between the stress-related pathways and eicosanoids. Here, we review the potential influences that stress, inflammation, and metabolic pathways have on each other, in the context of eicosanoids. Understanding the intricacies of such interactions could provide insights on how systemic metabolic effects mediated by the stress pathways can be translated into therapies for cancer and other diseases.

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Funding

This work is supported, in part, by the National Institutes of Health (CA016672, CA109298, CA193249, UH3TR000943, P50 CA217685, P50 CA083639, R35 CA209904), Ovarian Cancer Research Fund, Inc. (Program Project Development Grant), the Blanton-Davis Ovarian Cancer Research Program, the American Cancer Society Research Professor Award, and the Frank McGraw Memorial Chair in Cancer Research (A.K.S.).

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Author notes

  1. Sujanitha Umamaheswaran and Santosh K. Dasari have contributed equally.

Authors and Affiliations

  1. Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Unit 1362, 1515 Holcombe Blvd., Houston, TX, 77030, USA

    Sujanitha Umamaheswaran, Santosh K. Dasari & Anil K. Sood

  2. Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Sujanitha Umamaheswaran & Anil K. Sood

  3. Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Peiying Yang

  4. Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA

    Susan K. Lutgendorf

  5. Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA, USA

    Susan K. Lutgendorf

  6. Department of Urology, University of Iowa, Iowa City, IA, USA

    Susan K. Lutgendorf

  7. Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA

    Susan K. Lutgendorf

  8. Center for RNA Interference and Non-coding RNA, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Anil K. Sood

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  1. Sujanitha Umamaheswaran
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Correspondence to Anil K. Sood.

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Sujanitha Umamaheswaran and Santosh K. Dasari are co-first authors

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Umamaheswaran, S., Dasari, S.K., Yang, P. et al. Stress, inflammation, and eicosanoids: an emerging perspective. Cancer Metastasis Rev 37, 203–211 (2018). https://doi.org/10.1007/s10555-018-9741-1

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