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Identification of subclinical myocardial dysfunction by Speckle Tracking Imaging in patients with myocardial infarction with non-occlusive coronary arteries (MINOCA)

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Abstract

Purpose

The objective of this study was to investigate subclinical left ventricular dysfunction in patients diagnosed with myocardial infarction with non-occlusive coronary arteries (MINOCA).

Methods

Thirty-five patients with MINOCA (average age 54.26 ± 12.24 years) and thirty-five patients with ischemia with non-obstructed coronary artery disease (INOCA) (average age 55.20 ± 8.36 years) were enrolled in the study. All clinical conditions that could affect left ventricular functions were considered exclusion criteria. Echocardiographic studies were conducted in the patient and control groups in the left lateral decubitus position using a medical ultrasound device (EPIQ 7, Philips Medical System, USA). The left ventricle was examined longitudinally with apical images of chamber 4-3-2 using the available software (QLAB 6.0).

Results

There were no differences in age, blood pressure level, baseline echocardiogram measurements, and tissue Doppler parameters between the two groups. In two-dimensional speckle tracking echocardiography (2D-STE) measurements, left ventricular longitudinal strain and strain rate in systole, early and late diastole from apical 4-3-2 chamber and global measurements of each parameter were significantly decreased in the MINOCA group compared to the INOCA group (p < 0.05). A significant negative correlation was observed between the global longitudinal strain rate and the troponin I in the MINOCA patients group (r=-0.43 p = 0.009).

Conclusions

Our study showed that while standard echocardiographic parameters for patients diagnosed with MINOCA were normal, their left ventricular systolic and diastolic functions were reduced by the 2D-STE method.

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Acknowledgements

None Conflict of interest: None.

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Authors and Affiliations

  1. Department of Cardiology, Faculty of Medicine, Aksaray University, Aksaray, Turkey

    Sinan INCI, Murat GUL MD, Deniz ELCIK, Halil AKTAS, Oguz YILDIRIM, Saban KELESOGLU & Nihat KALAY

  2. Department of Cardiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey

    Sinan INCI, Murat GUL MD, Deniz ELCIK, Halil AKTAS, Oguz YILDIRIM, Saban KELESOGLU & Nihat KALAY

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  1. Sinan INCI
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Contributions

Sinan Inci: Conceptualization, Data curation, Formal analysis, Writing original draft.

Murat Gul: Methodology, Formal analysis, Writing original draft.

Deniz Elcik: Investigation, Data curation, Validation.

Halil Aktas: Methodology, Data curation.

Oguz Yildirim: Investigation, Validation, Data curation.

Saban Kelesoglu: Investigation, Validation, Writing, Review & Editing.

Nihat KALAY: Project administration, Review & Editing.

Corresponding author

Correspondence to Murat GUL MD.

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Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

Conflict of interest

/Competing interests: The authors have no relevant financial or non-financial interests to disclose.

Ethics approval:

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Clinical Research Ethics Committee of University Erciyes (Date:29.04.2020/No:2020/205).

Informed consent:

The informed consent was taken from all patients, and the study was approved by the local ethics committee (No: 2020/205, Date: 29.04.2020).

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INCI, S., GUL, M., ELCIK, D. et al. Identification of subclinical myocardial dysfunction by Speckle Tracking Imaging in patients with myocardial infarction with non-occlusive coronary arteries (MINOCA). Int J Cardiovasc Imaging 38, 2099–2106 (2022). https://doi.org/10.1007/s10554-022-02602-2

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  • DOI: https://doi.org/10.1007/s10554-022-02602-2

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