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Highly accelerated cardiac MRI using iterative SENSE reconstruction: initial clinical experience

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Abstract

To evaluate the qualitative and quantitative performance of an accelerated cardiovascular MRI (CMR) protocol that features iterative SENSE reconstruction and spatio-temporal L1-regularization (IS SENSE). Twenty consecutively recruited patients and 9 healthy volunteers were included. 2D steady state free precession cine images including 3-chamber, 4-chamber, and short axis slices were acquired using standard parallel imaging (GRAPPA, acceleration factor = 2), spatio-temporal undersampled TSENSE (acceleration factor = 4), and IS SENSE techniques (acceleration factor = 4). Acquisition times, quantitative cardiac functional parameters, wall motion abnormalities (WMA), and qualitative performance (scale: 1-poor to 5-excellent for overall image quality, noise, and artifact) were compared. Breath-hold times for IS SENSE (3.0 ± 0.6 s) and TSENSE (3.3 ± 0.6) were both reduced relative to GRAPPA (8.4 ± 1.7 s, p < 0.001). No difference in quantitative cardiac function was present between the three techniques (p = 0.89 for ejection fraction). GRAPPA and IS SENSE had similar image quality (4.7 ± 0.4 vs. 4.5 ± 0.6, p = 0.09) while, both techniques were superior to TSENSE (quality: 4.1 ± 0.7, p < 0.001). GRAPPA WMA agreement with IS SENSE was good (κ > 0.60, p < 0.001), while agreement with TSENSE was poor (κ < 0.40, p < 0.001). IS SENSE is a viable clinical CMR acceleration approach to reduce acquisition times while maintaining satisfactory qualitative and quantitative performance.

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Authors and Affiliations

  1. Department of Radiology, Northwestern University, 737 N. Michigan Ave, Suite 1600, Chicago, IL, 60611, USA

    Bradley D. Allen, Maria Carr, Marcos P. F. Botelho, Amir Ali Rahsepar, Michael Markl, Jeremy D. Collins & James C. Carr

  2. Department of Biomedical Engineering, Northwestern University, Chicago, IL, USA

    Michael Markl

  3. MR Collaborations, Siemens Medical Solutions USA Inc., Malvern, PA, USA

    Michael O. Zenge & Bruce Spottiswoode

  4. Siemens Healthcare GmbH, Erlangen, Germany

    Michaela Schmidt

  5. Medical Imaging Technologies, Siemens Healthcare, Princeton, NJ, USA

    Mariappan S. Nadar

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  1. Bradley D. Allen
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  2. Maria Carr
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  3. Marcos P. F. Botelho
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  4. Amir Ali Rahsepar
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Correspondence to Bradley D. Allen.

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Conflict of interest

Authors MOZ, MS, MSN, and BS are employees of Siemens Healthcare. Authors BA, MC, MPFB, AAR, MM, JDC, and JCC all declare no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study except in cases where informed consent was waived by the local institutional review board.

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Allen, B.D., Carr, M., Botelho, M.P.F. et al. Highly accelerated cardiac MRI using iterative SENSE reconstruction: initial clinical experience. Int J Cardiovasc Imaging 32, 955–963 (2016). https://doi.org/10.1007/s10554-016-0859-3

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  • DOI: https://doi.org/10.1007/s10554-016-0859-3

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