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Normal mitral annulus dynamics and its relationships with left ventricular and left atrial function

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Abstract

Mitral annulus (MA) geometry and dynamics are crucial for preserving normal mitral valve (MV) function. Static reference values for MA parameters have been reported, but the normal MA dynamics during the entire cardiac cycle remains controversial. MV full-volume datasets were obtained by three-dimensional transthoracic echocardiography from 50 healthy volunteers (18–74 years; 31 men) to assess MA changes in size and shape during entire cardiac cycle. Using simultaneous multiplanar review, projected MA area (MAA) and circumference (MAC), antero-posterior (AP) and anterolateral-posteromedial (ALPM) diameters, and sphericity index (SphI) were obtained at: mitral valve closure (MVC), mid- and end-systole (ES), early- (EDF) and late-diastolic filling, and end-diastole. MAA and AP diameter were the most “active” parameters, changing in all reference frames (p < 0.001). MAA and AP diameter started to contract before MVC (during the left atrial contraction), reaching their minimum at MVC. Maximum MAA occurred at ES, while maximum AP diameter and SphI occurred at EDF. MAA fractional shortening was 35 ± 10 %. AP diameter change was 25 ± 10 %. MAC, ALPM and SphI showed similar patterns during left ventricular (LV) systole, and remained unchanged during diastole. Fractional change was 35 ± 10 % for MAC, and 13 ± 8 % for ALPM diameter. Our study provides the normal dynamics of the MA during the entire cardiac cycle. It reveals “pre-systolic” contraction of the MA, related to left atrial (LA) contraction, and minimal MAA during early LV systole. Therefore, the normal MA dynamics relates to a “physiologic LA-LV coupling”, and a complete MA contraction requires both and properly timed LA and LV systole.

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Abbreviations

2D:

Two-dimensional

3D:

Three-dimensional

ALPM:

Anterolateral-posteromedial

AP:

Anterior-posterior

ED:

End-diastole

EDF:

Early diastolic filling

ES:

End-systole

LA:

Left atrium

LDF:

Late diastolic filling

LV:

Left ventricle

MA:

Mitral annulus

MR:

Mitral regurgitation

MS:

Mid-systole

MV:

Mitral valve

MVC:

Mitral valve closure

SphI:

Sphericity index

TTE:

Transthoracic echocardiography

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Acknowledgments

Dr. Mihaila is an EACVI Research Grant winner on 2011 and an ESC Training Grant winner on 2014. Dr Mihaila is also a winner of a Grant for PhD research of the University of Medicine and Pharmacy “Carol Davila” Bucharest, POSDRU/159/1.5/S/141531.

Conflict of interest

Doctors Badano and Muraru are consultants and received equipment grants from GE Healthcare and TomTec Imaging Systems.

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Authors and Affiliations

  1. Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Via Giustiniani 2, 35128, Padua, Italy

    Sorina Mihaila, Denisa Muraru, Marcelo Haertel Miglioranza, Eleonora Piasentini, Diletta Peluso, Umberto Cucchini, Sabino Iliceto & Luigi P. Badano

  2. University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania

    Sorina Mihaila & Dragos Vinereanu

  3. Cardiology Institute of Rio Grande Do Sul, Porto Alegre, Brazil

    Marcelo Haertel Miglioranza

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  1. Sorina Mihaila
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  2. Denisa Muraru
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Correspondence to Sorina Mihaila.

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Mihaila, S., Muraru, D., Miglioranza, M.H. et al. Normal mitral annulus dynamics and its relationships with left ventricular and left atrial function. Int J Cardiovasc Imaging 31, 279–290 (2015). https://doi.org/10.1007/s10554-014-0547-0

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  • DOI: https://doi.org/10.1007/s10554-014-0547-0

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