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Secondary cancer after meningioma diagnosis: an Israeli national study

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Abstract

Background

There are limited data on whether primary diagnosis of meningioma may be associated with development of secondary primary cancer (SPC).

Methods

All meningioma cases (ICD-O-3 morphology codes 9530/0–9539/3) diagnosed in Jewish Israelis ≥ 20 years 1990 through 2015 registered in the Israel National Cancer Registry (INCR) were retrieved. All subsequent cancers occurring more than 6 months after meningioma diagnosis were identified. Risk of secondary cancer (SPC) was compared to cancer risk in the general population through the calculation of standardized incidence ratios (SIRs) and excess absolute risks (EARs). SIRs were stratified by type of second cancer, sex, and age group. Cox regression models were used to estimate hazard ratios of developing SPC.

Results

Overall, 8044 meningioma cases were identified: mean age at diagnosis was 64.0 ± 14.1 years. Of these, 927 (11.5%) were diagnosed with SPC (SIR 1.6, 95% CI 1.5–1.7). SPC risk was elevated in men (SIR 1.6, 95% CI 1.5–1.9) and women (SIR 1.6, 95% CI 1.5–1.8) diagnosed with meningioma in univariable analyses. Cancers most commonly encountered in the studied population were breast (17.6%), colorectal (13.4%), lung (8.1%), prostate (5%), and bladder (4.6%) cancer. In multivariable analyses, 10+ year increment in age at meningioma diagnosis was significantly associated with higher risk for SPC in individuals diagnosed with meningioma between 20 and 64 years, with an inverse association in the older age group (65+ years).

Conclusions

Meningioma diagnosis is associated with an increased risk for developing secondary cancers. This risk should be discussed with patients treated for meningioma.

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Data availability

The data underlying this article will be shared on reasonable request to the corresponding author.

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Funding

No funding was received for conducting this study.

Author information

Author notes

  1. Maya Ben Lassan and Yael Laitman have equally contributed to this work.

Authors and Affiliations

  1. Israeli National Cancer Registry, Ministry of Health, Tel-Hashomer, Ramat Gan, Israel

    Maya Ben Lassan, Lital Keinan-Boker & Barbara Silverman

  2. The Oncogenetics Unit, Institute of Human Genetics, Sheba Medical Center, Tel-Hashomer, 52621, Ramat Gan, Israel

    Yael Laitman & Eitan Friedman

  3. School of Public Health, University of Haifa, Haifa, Israel

    Lital Keinan-Boker

  4. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

    Barbara Silverman & Eitan Friedman

Authors
  1. Maya Ben Lassan
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  2. Yael Laitman
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  3. Lital Keinan-Boker
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  4. Barbara Silverman
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  5. Eitan Friedman
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Corresponding author

Correspondence to Eitan Friedman.

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All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.

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The Institutional Review Board of the Sheba Medical center approved the study.

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Ben Lassan, M., Laitman, Y., Keinan-Boker, L. et al. Secondary cancer after meningioma diagnosis: an Israeli national study. Cancer Causes Control 33, 1277–1284 (2022). https://doi.org/10.1007/s10552-022-01609-3

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  • DOI: https://doi.org/10.1007/s10552-022-01609-3

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