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Associations of change in television viewing time with biomarkers of postmenopausal breast cancer risk: the Australian Diabetes, Obesity and Lifestyle Study

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Abstract

Purpose

Sedentary behavior has been previously shown, in a cross-sectional study, to have deleterious associations with biomarkers of postmenopausal breast cancer risk. We examined the associations of change in sedentary behavior [daily television (TV) viewing time, h/day] over a 5-year period with putative markers of postmenopausal breast cancer risk.

Methods

The analytic cohort consisted of 1,001 postmenopausal women from the Australian Diabetes, Obesity and Lifestyle (AusDiab) study (1999–2005). Multivariate linear regression models were used to examine associations of change in TV viewing time with biomarkers of the following risk mechanisms: adiposity (body mass index [BMI], waist circumference); metabolic dysfunction (fasting plasma glucose, 2-h plasma glucose, fasting insulin, insulin resistance [homeostasis model assessment of insulin resistance (HOMA-IR)]); and inflammation (high-sensitivity C-reactive protein (hs-CRP)). All analyses were adjusted for age, baseline TV viewing, and potential confounders.

Results

Hourly increments of change in TV viewing time were positively associated with BMI (β = 0.50, 95 % CI 0.20, 0.81; p = 0.001), waist circumference (β = 1.18, 95 % CI 0.49, 1.87; p = 0.001), fasting insulin (β = 38.13 %, 95 % CI 37.08, 39.20; p = 0.01) and HOMA-IR (β = 37.93 %, 95 % CI 36.92, 38.98; p = 0.03) in fully adjusted models. Significant associations with BMI, waist circumference, fasting insulin and HOMA-IR were also present in analyses using categories of change in TV viewing time (reduced, same, increased).

Conclusions

The findings suggest that increasing habitual sedentary behavior over time could increase breast cancer risk among postmenopausal women. Further investigation into the role of sedentary behavior in breast cancer etiology is warranted.

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Acknowledgments

Lynch and Cameron are supported by Early Career Fellowships from the National Health and Medical Research Council (586727 and 1013313). Dunstan is supported by a Future Fellowship from the Australian Research Council (FT100100918). Baker IDI Heart and Diabetes Institute receives support from the Victorian Government’s Operational Infrastructure Support Program. The AusDiab study, co-coordinated by Baker IDI Heart and Diabetes Institute, gratefully acknowledges the generous support given by National Health and Medical Research Council (NHMRC Grant 233200), Australian Government Department of Health and Ageing, Abbott Australasia Pty Ltd, Alphapharm Pty Ltd, AstraZeneca, Bristol-Myers Squibb, City Health Centre-Diabetes Service—Canberra, Department of Health and Community Services—Northern Territory, Department of Health and Human Services—Tasmania, Department of Health—New South Wales, Department of Health—Western Australia, Department of Health—South Australia, Department of Human Services—Victoria, Diabetes Australia, Diabetes Australia Northern Territory, Eli Lilly Australia, Estate of the Late Edward Wilson, GlaxoSmithKline, Jack Brockhoff Foundation, Janssen-Cilag, Kidney Health Australia, Marian and FH Flack Trust, Menzies Research Institute, Merck Sharp and Dohme, Novartis Pharmaceuticals, Novo Nordisk Pharmaceuticals, Pfizer Pty Ltd, Pratt Foundation, Queensland Health, Roche Diagnostics Australia, Royal Prince Alfred Hospital, Sydney, Sanofi Aventis, Sanofi Synthelabo. The AusDiab study was also supported in part by the Victorian Government’s OIS Program. We acknowledge the AusDiab project manager Shirley Murray and administrative associate Sue Fournel for the contribution to the study. We also thank the field coordinators Marita Dalton (1999–2000), Theresa Whalen (2004–2005) and Annaliese Bonney (2004–2005), as well as all the AusDiab support staff from 1999/2000 and 2004/2005. We would like to thank the participants for volunteering their time to participate in the AusDiab study.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

All Australian legal and ethical standards and protocols were adhered to during the implementation of this study.

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Authors and Affiliations

  1. Physical Activity Laboratory, Baker IDI Heart and Diabetes Institute, Level 4, 99 Commercial Road, Melbourne, VIC, 3004, Australia

    Allan J. Wiseman, Brigid M. Lynch & David W. Dunstan

  2. Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Melbourne, VIC, Australia

    Allan J. Wiseman, Adrian J. Cameron & David W. Dunstan

  3. Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia

    Brigid M. Lynch

  4. WHO Collaborating Centre for Obesity Prevention, Deakin University, Melbourne, VIC, Australia

    Adrian J. Cameron

  5. School of Population Health, The University of Queensland, Brisbane, QLD, Australia

    David W. Dunstan

  6. School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia

    David W. Dunstan

  7. School of Sports Science, Exercise and Health, The University of Western Australia, Perth, WA, Australia

    David W. Dunstan

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  1. Allan J. Wiseman
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  2. Brigid M. Lynch
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  3. Adrian J. Cameron
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  4. David W. Dunstan
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Corresponding author

Correspondence to David W. Dunstan.

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Wiseman, A.J., Lynch, B.M., Cameron, A.J. et al. Associations of change in television viewing time with biomarkers of postmenopausal breast cancer risk: the Australian Diabetes, Obesity and Lifestyle Study. Cancer Causes Control 25, 1309–1319 (2014). https://doi.org/10.1007/s10552-014-0433-z

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  • DOI: https://doi.org/10.1007/s10552-014-0433-z

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