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Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract

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Abstract

Objectives

The purpose of this study was to investigate the role of polymorphisms of genes involved in inflammation in the risk of cancers of the upper aerodigestive tract (UADT).

Methods

We have evaluated the role of polymorphisms in key genes related to inflammation, namely IL1B (rs1143627), COX2/PTGS2 (rs5275), and IL8 (rs4073) in a large case–control study comprising 811 UADT cancer cases and 1,083 controls.

Results

An association was observed for squamous cell carcinoma of the pharynx for a polymorphism in the promoter of the IL1B gene, with an OR of 2.39 (95% CI = 1.19–4.81) for the homozygotes for the minor allele A promoter polymorphism of IL8 was associated with decreased risk of laryngeal cancer, with an OR of 0.70 (95% CI = 0.50–0.98) for carriers of the minor allele.

Conclusions

To our knowledge, this is the first report on the role of these polymorphisms with respect to UADT carcinogenesis. Our results suggest that inflammation-related polymorphisms play a role, albeit minor, in the risk of developing cancers of the upper aerodigestive tract.

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Acknowledgments

This work was supported by grants from the European Commission’s INCO-COPERNICUS Program (Contract No. IC15-CT98-0332), the US National Institutes of Health/National Cancer Institute (CA92039) and the World Cancer Research Foundation (WCRF 99A28). Daniele Campa was a recipient of a fellowship by the University of Pisa and a special training award by the International Agency for Research on Cancer.

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Authors and Affiliations

  1. International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon, France

    Daniele Campa, Mia Hashibe, Valérie Gaborieau, Rayjean J. Hung, Paolo Boffetta, Paul Brennan & Federico Canzian

  2. Department of Biology, Universita’ di Pisa, Via S. Giuseppe 22, 56100, Pisa, Italy

    Daniele Campa

  3. Institute of Carcinogenesis, Cancer Research Center, Moscow, Russia

    David Zaridze

  4. Department of Occupational and Environmental Epidemiology, Institute of Occupational Medicine, Lodz, Poland

    Neonila Szeszenia-Dabrowska

  5. University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania

    Ioan Nicolae Mates

  6. Department of Preventive Medicine, Faculty of Medicine, Palacky University, Olomouc, Czech Republic

    Vladimir Janout

  7. Institute of Hygiene and Epidemiology, First Faculty of Medicine, Charles University, Prague, Czech Republic

    Ivana Holcatova

  8. Department of Occupational Health, Specialized State Health Institute, Banska Bystrica, Slovakia

    Eleonóra Fabiánová

  9. German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany

    Federico Canzian

Authors
  1. Daniele Campa
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  2. Mia Hashibe
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  3. David Zaridze
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  4. Neonila Szeszenia-Dabrowska
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  5. Ioan Nicolae Mates
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  6. Vladimir Janout
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  7. Ivana Holcatova
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  8. Eleonóra Fabiánová
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  9. Valérie Gaborieau
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  10. Rayjean J. Hung
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  11. Paolo Boffetta
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  12. Paul Brennan
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  13. Federico Canzian
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Corresponding author

Correspondence to Federico Canzian.

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Campa, D., Hashibe, M., Zaridze, D. et al. Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract. Cancer Causes Control 18, 449–455 (2007). https://doi.org/10.1007/s10552-007-0129-8

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  • DOI: https://doi.org/10.1007/s10552-007-0129-8

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