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Mitochondrial NADH-dehydrogenase subunit 3 (ND3) polymorphism (A10398G) and sporadic breast cancer in Poland

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Abstract

Mitochondria are subcellular organelles that produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). As suggested over 70 years ago by Otto Warburg and recently confirmed with molecular techniques, alterations in respiratory activity and mitochondrial DNA (mtDNA) appear to be common features of malignant cells. Somatic mtDNA mutations have been reported in many types of cancer cells, but very few reports document the prevalence of inherited mitochondrial DNA polymorphisms in cancer patients compared to healthy control populations. Here we report the abundance of the 10398G polymorphism in a Polish breast cancer population and its frequency in controls. Amongst individuals with breast cancer the G single nucleotide polymorphism (SNP) is present in 23% of affected females compared to 3% of controls. This difference is highly statistically significant (P = 0.0008). It is therefore possible that the 10398G SNP constitutes an inherited predisposition factor for the development of breast cancer.

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Acknowledgments

This work was supported by grants from the National Institutes of Health (USA) to JP (CA.96994 and CA98912). AMC was supported by Fulbright Junior Research Grant and The Kosciuszko Foundation Scholarship. The authors thank Przemysław Tomalski, Centre for Brain and Cognitive Development, School of Psychology, Birkbeck College, UK) and Marek Kudła (WSBS, CSHL, NY, USA) for fruitful discussions.

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Authors and Affiliations

  1. Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, ul. Pawińskiego 5a, 02-106, Warsaw, Poland

    Anna M. Czarnecka, Paweł Golik & Ewa Bartnik

  2. School of Molecular Medicine, Medical University of Warsaw, ul. Żwirki i Wigury 61, 02-091, Warsaw, Poland

    Anna M. Czarnecka

  3. Clinical Pathology Laboratory, Monument Institute of Polish Mothers Health Center, Lodz, Poland

    Tomasz Krawczyk

  4. Department of Oncological Surgery and Breast Diseases, Monument Institute of Polish Mothers Health Center, Lodz, Poland

    Marek Zdrożny

  5. Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland

    Jan Lubiński

  6. Department of Urology, Emory University School of Medicine, 1365 Clifton Rd., Building B, Atlanta, GA, 30322, USA

    Rebecca S. Arnold & John A. Petros

  7. Department of Otolaryngology, Czerniakowski Hospital, Warsaw Medical University, Warsaw, Poland

    Wojciech Kukwa & Anna Ścińska

  8. Institute of Biochemistry and Biophysics, The Polish Academy of Sciences, Warsaw, Poland

    Paweł Golik & Ewa Bartnik

  9. The Atlanta VA Medical Center, 1670 Clairmont Rd., Decatur, GA, 30033, USA

    John A. Petros

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  1. Anna M. Czarnecka
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Correspondence to John A. Petros.

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Czarnecka, A.M., Krawczyk, T., Zdrożny, M. et al. Mitochondrial NADH-dehydrogenase subunit 3 (ND3) polymorphism (A10398G) and sporadic breast cancer in Poland. Breast Cancer Res Treat 121, 511–518 (2010). https://doi.org/10.1007/s10549-009-0358-5

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