Abstract
Interleukin-10 (IL-10) is an immunosuppressive cytokine which may facilitate development of cancer by supporting tumor escape from the immune response. A [TCATA] haplotype formed by polymorphisms at positions −3575, −2763, −1082, −819 and −592 in the promoter of the IL-10 gene is a strong determinant for IL-10 expression. The presence of this haplotype can be determined by analysis of the −592C > A polymorphism. Aim of the present study was to analyze the role of the IL-10 [TCATA] haplotype for breast cancer. We performed a case–control study including 500 female patients with histologically confirmed breast cancer and 500 female, age-matched, healthy control subjects from population-based screening studies. The −592C > A polymorphism was determined by a 5′-nuclease assay (TaqMan). Frequency of the homozygous −592 AA genotype, indicating homozygosity for the [TCATA] haplotype, was 4.2% among patients and 7.3% among controls (p=0.038; odds ratio 0.56; 95% confidence interval 0.32–0.97). IL-10 genotypes were not associated with tumor size, histological grading, estrogen or progesterone receptor status and age at diagnosis. Therefore we conclude that the IL-10 −592C > A promoter polymorphism may be associated with a reduced breast cancer risk.
Similar content being viewed by others
References
S Mocellin F Marincola CR Rossi D Nitti M Lise (2004) ArticleTitleThe multifaceted relationship between IL-10 and adaptive immunity: putting together the pieces of a puzzle Cytokine Growth Factor Rev 15 61–76
MT Lin B Storer PJ Martin LH Tseng T Gooley PJ Chen JA Hansen (2003) ArticleTitleRelation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation N Engl J Med 349 2201–2210
P Krippl U Langsenlehner W Renner B Yazdani-Biuki G Wolf TC Wascher B Paulweber J Haas HA Samonigg (2003) ArticleTitlecommon 936 C/T gene polymorphism of vascular endothelial growth factor is associated with decreased breast cancer risk Int J Cancer 106 468–471
U Langsenlehner P Krippl W Renner B Yazdani-Biuki G Wolf TC Wascher B Paulweber W Weitzer H Samonigg (2003) ArticleTitleThe common 677C > T gene polymorphism of methylenetetrahydrofolate reductase gene is not associated with breast cancer risk Breast Cancer Res Treat 81 169–172
P Krippl U Langsenlehner W Renner B Yazdani-Biuki G Wolf TC Wascher B Paulweber W Weitzer A Leithner H Samonigg (2003) ArticleTitleThe 870G > A polymorphism of the Cyclin D1 gene is not associated with breast cancer Breast Cancer Res Treat 82 165–168
P Krippl U Langsenlehner W Renner B Yazdani-Biuki H Koppel A Leithner TC Wascher B Paulweber H Samonigg (2004) ArticleTitleThe 5A/6A polymorphism of the matrix metalloproteinase 3 gene promoter and breast cancer Clin Cancer Res 10 3518–20
RM Scarel-Caminaga PC Trevilatto AP Souza RB Brito LE Camargo SR Line (2004) ArticleTitleInterleukin 10 gene promoter polymorphisms are associated with chronic periodontitis J Clin Periodontol 31 443–448
S George XZ Ruan C Navarrete D Turner M Reynard P Sweny G Hamilton DC Wheeler SH Powis JF Moorhead Z Varghese (2004) ArticleTitleRenovascular disease is associated with low producer genotypes of the anti-inflammatory cytokine interleukin-10 Tissue Antigens 63 470–475
L Giordani P Bruzzi C Lasalandra M Quaranta F Schittulli F Della Ragione A Iolascon (2003) ArticleTitleAssociation of breast cancer and polymorphisms of interleukin-10 and tumor necrosis factor-alpha genes. Clin Chem 49 1664–1667
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Langsenlehner, U., Krippl, P., Renner, W. et al. Interleukin-10 promoter polymorphism is associated with decreased breast cancer risk. Breast Cancer Res Treat 90, 113–115 (2005). https://doi.org/10.1007/s10549-004-3607-7
Issue Date:
DOI: https://doi.org/10.1007/s10549-004-3607-7