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EEG and fMRI Coregistration to Investigate the Cortical Oscillatory Activities During Finger Movement

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Abstract

Electroencephalography combined with functional magnetic resonance imaging (EEG-fMRI) may be used to identify blood oxygenation level dependent (BOLD) signal changes associated with physiological and pathological EEG event. In this study we used EEG-fMRI to determine the possible correlation between topographical movement-related EEG changes in brain oscillatory activity recorded from EEG electrodes over the scalp and fMRI-BOLD cortical responses in motor areas during finger movement. Thirty-two channels of EEG were recorded in 9 subjects during eyes-open condition inside a 1.5 T magnetic resonance (MR) scanner using a MR-compatible EEG recording system. Off-line MRI artifact subtraction software was applied to obtain continuous EEG data during␣fMRI acquisition. For EEG data analysis we used the event-related-synchronization/desynchronization (ERS/ERD) approach to investigate where movement-related decreases in alpha and beta power are located. For image statistical analysis we used a general linear model (GLM) approach. There was a significant correlation between the positive-negative ratio of BOLD signal peaks and ERD values in the electrodes over the region of activation. We conclude that combined EEG-fMRI may be used to investigate movement-related oscillations of the human brain inside an MRI scanner and the movement-related changes in the EMG or EEG signals are useful to identify the brain activation sources responsible for BOLD-signal changes.

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Acknowledgments

The authors wish to thank Profs. Gianna Maria Toffolo and Alessandra Bertoldo (Department of Information Engineering, University of Padova) for help and advice concerning statistical analysis. This work was supported by Crediveneto, Verona, Italy.

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Authors and Affiliations

  1. Section of Neurological Rehabilitation, Department of Neurological and Visual Sciences, “Gianbattista Rossi” Hospital, University of Verona, P.le Scuro, 37134, Verona, Italy

    Emanuela Formaggio, Silvia Francesca Storti, Mirko Avesani, Franco Milanese, Michele Acler, Antonio Fiaschi & Paolo Manganotti

  2. Department of Information Engineering, University of Padova, Padova, Italy

    Emanuela Formaggio

  3. Department of Morphologic and Biomedical Sciences, “Gianbattista Rossi” Hospital, University of Verona, Verona, Italy

    Roberto Cerini, Anna Gasparini & Roberto Pozzi Mucelli

  4. IRCCS “San Camillo” Hospital, Venice, Italy

    Antonio Fiaschi

Authors
  1. Emanuela Formaggio
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  2. Silvia Francesca Storti
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  3. Mirko Avesani
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  4. Roberto Cerini
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  5. Franco Milanese
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  6. Anna Gasparini
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  7. Michele Acler
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  8. Roberto Pozzi Mucelli
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  9. Antonio Fiaschi
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  10. Paolo Manganotti
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Correspondence to Emanuela Formaggio.

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Formaggio, E., Storti, S.F., Avesani, M. et al. EEG and fMRI Coregistration to Investigate the Cortical Oscillatory Activities During Finger Movement. Brain Topogr 21, 100–111 (2008). https://doi.org/10.1007/s10548-008-0058-1

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  • DOI: https://doi.org/10.1007/s10548-008-0058-1

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