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Long term performance of porous platinum coated neural electrodes

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Abstract

Over the last several years, there has been a growing interest in neural implants for the study and diagnostics of neurological disorders as well as for the symptomatic treatment of central nervous system related diseases. One of the major challenges is the trade-off between small electrode sizes for high selectivity between single neurons and large electrode-tissue interface areas for excellent stimulation and recording properties. This paper presents an approach of increasing the real surface area of the electrodes by creating a surface microstructure. Two major novelties let this work stand out from existing approaches which mainly make use of porous coatings such as platinum black or iridium oxide, or Poly(3,4-ethylenedioxythiophene) (PEDOT). Roughening is carried out by a dry etching process on the silicon electrode core before being coated by a sputtered platinum layer, eliminating complicated deposition processes as for the materials described above. The technology is compatible with any commonly used coating material. In addition, the surface roughening is compatible with high aspect ratio penetrating electrode arrays such as the well-established Utah electrode array, whose unique geometry presents a challenge in the surface modification of active electrode sites. The dry etching process is well characterized and yields a high controllability of pore size and depth. This paper confirms the superior electrochemical properties including impedance, charge injection capacity, and charge storage capacity of surface engineered electrode arrays compared to conventional arrays over a period of 12 weeks. Furthermore, mechanical stability of the modified electrodes was tested by implantation in the brain of a recently deceased rat. In conclusion, the larger interface surface of the electrodes does not only decrease the impedance which should lead to enhanced Signal to noise ratio (SNR) for recording purposes, but also yields higher charge injection capacities, which improve the stimulation characteristics of the implants.

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Acknowledgments

Research reported in this publication was supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Award Number 1R43NS082036. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors would like to thank Mr. Ryan Caldwell, Dr. Mohit Diwekar, and Prof. Henry White for their help and advice. This work was performed in part at the Utah Nanofab sponsored by the College of Engineering, Office of the Vice President for Research, and the Utah Science Technology and Research (USTAR) initiative of the State of Utah. The authors appreciate the support of the staff and facilities that made this work possible. This work made use of University of Utah shared facilities of the Micron Technology Foundation Inc. Microscopy Suite sponsored by the College of Engineering, Health Sciences Center, Office of the Vice President for Research, and the Utah Science Technology and Research (USTAR) initiative of the State of Utah. This work made use of University of Utah USTAR shared facilities supported, in part, by the MRSEC Program of the NSF under Award No. DMR-1121252.

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Authors and Affiliations

  1. Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, USA

    M. Leber, R. Bhandari, M. M. H. Shandhi, F. Solzbacher & S. Negi

  2. Blackrock Microsystems, Salt Lake City, UT, USA

    R. Bhandari & S. Negi

  3. Department of Bioengineering, University of Utah, Salt Lake City, UT, USA

    J. Mize & D. J. Warren

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  1. M. Leber
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  2. R. Bhandari
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  6. F. Solzbacher
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Correspondence to M. Leber.

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Florian Solzbacher, Rajmohan Bhandari, and Sandeep Negi have financial interest in the company Blackrock Microsystems, which develops and produces implantable neural interfaces, and electrophysiology equipment and software.

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Research reported in this publication was supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Award Number 1R43NS082036.

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Leber, M., Bhandari, R., Mize, J. et al. Long term performance of porous platinum coated neural electrodes. Biomed Microdevices 19, 62 (2017). https://doi.org/10.1007/s10544-017-0201-4

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