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Metal-responsive gene regulation and metal transport in Helicobacter species

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Abstract

Helicobacter species are among the most successful colonizers of the mammalian gastrointestinal and hepatobiliary tract. Colonization is usually lifelong, indicating that Helicobacter species have evolved intricate mechanisms of dealing with stresses encountered during colonization of host tissues, like restriction of essential metal ions. The recent availability of genome sequences of the human gastric pathogen Helicobacter pylori, the murine enterohepatic pathogen Helicobacter hepaticus and the unannotated genome sequence of the ferret gastric pathogen Helicobacter mustelae has allowed for comparitive genome analyses. In this review we present such analyses for metal transporters, metal-storage and metal-responsive regulators in these three Helicobacter species, and discuss possible contributions of the differences in metal metabolism in adaptation to the gastric or enterohepatic niches occupied by Helicobacter species.

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Acknowledgement

We thank Dr Paul O’Toole and Dr Julian Parkhill for access to the unpublished genome sequence of H. mustelae. The sequencing of the H. mustelae genome is funded by the Wellcome Trust.

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  1. Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Room L-455, ’s Gravendijkwal 230, 3015CE, Rotterdam, The Netherlands

    Clara Belzer, Jeroen Stoof & Arnoud H. M. van Vliet

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  1. Clara Belzer
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Correspondence to Arnoud H. M. van Vliet.

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Belzer, C., Stoof, J. & van Vliet, A.H.M. Metal-responsive gene regulation and metal transport in Helicobacter species. Biometals 20, 417–429 (2007). https://doi.org/10.1007/s10534-006-9028-9

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