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Inhibitory effect of curcumin on liver injury in a murine model of endotoxemic shock

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Abstract

The effect of curcumin on lipopolysaccharide/d-galactosamine (LPS/GalN)-induced acute shock model of liver injury was examined in mice. The simultaneous administration of LPS (5–20 μg kg−1, i.p.) and GalN (700 mg kg−1, i.p.) markedly increased the serum tumor necrosis factor-α (TNF-α), glutamic oxaloacetic transaminase/glutamic pyruvic transaminase (GOT/GPT), and massive hepatic necrosis and inflammation, leading to 100% lethality. Pre-administration of curcumin (100 mg kg−1, i.p.) 3 h before induction with LPS/GalN imparted a large extent of protection against acute elevation in serum TNF-α and serum GOT/GPT. Hepatic necrosis and lethality caused by LPS/GalN was also greatly reduced by curcumin treatment. The results demonstrated that curcumin could protect mice from LPS/GalN-induced hepatic injury and inflammation through blockading TNF-α production, eventually raising the survival rate of septic-shock-induced mice.

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Acknowledgements

This work received grant support from the Agenda Program (No. 200901OFT113068122), Rural Development Administration, Republic of Korea.

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Authors and Affiliations

  1. Department of Biological Science, Ajou University, Suwon, 443-749, Republic of Korea

    Sang Sik Yun & Seok Hyun Nam

  2. Department of Molecular Science and Technology, Ajou University, Suwon, 443-749, Republic of Korea

    Sung Phil Kim

  3. Department of Food Science and Nutrition, Kyungpook National University, Daegu, 702-701, Republic of Korea

    Mi Young Kang

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  1. Sang Sik Yun
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  2. Sung Phil Kim
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  4. Seok Hyun Nam
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Correspondence to Seok Hyun Nam.

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Yun, S.S., Kim, S.P., Kang, M.Y. et al. Inhibitory effect of curcumin on liver injury in a murine model of endotoxemic shock. Biotechnol Lett 32, 209–214 (2010). https://doi.org/10.1007/s10529-009-0153-8

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  • DOI: https://doi.org/10.1007/s10529-009-0153-8

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