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Influence of the rs4238001 Genetic Polymorphism of the SR-B1 Gene on Serum Lipid Levels and Response to Rosuvastatin in Myocardial Infarction Iraqi Patients

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Abstract

Scavenger receptor type B (SR-BI) is a receptor that binds both native and altered lipoproteins. It was revealed to facilitate utilization of high-density lipoprotein HDL and significantly affect the reverse transport of cholesterol. Therefore, the objectives were to identify the possible role of the genetic variant rs4238001 in patients with myocardial infarction (MI) on serum lipid level, and how this variant could impact the response of rosuvastatin drug. The genotyping of the rs4238001 genetic polymorphism of the SR-B1 gene was performed in 300 participants, including 150 MI patients treated with 20mg/day/4 weeks of rosuvastatin and 150 healthy control using Taq man probes (FAM and VIC) by Real-time PCR technique. The concentrations of the lipid profile were evaluated. The significance of the anthropometric data was revealed in the ejection fraction and smoking status (p < 0.05) between groups. The lipid profile shows either significant differences between control and MI patients (pre-treatment) or between pre-and post-treatment of MI patients (p < 0.05), but not HDL-c (p > 0.05). The minor allele frequency MAF% of the T allele and TT genotype were more frequent in MI patients than in controls (P = 0.173; OR = 3.62; 95% CI = 0.74–17.64). CC genotype was found to be associated with response to rosuvastatin therapy with a change of % (29.08 ± 53.2; p = 0.021). In the Iraqi population, the rs4238001 polymorphism of the SR-B1 gene is associated with variations in serum lipids, and the CC genotype of the SNP is related to higher HDL-C in the lipid-lowering rosuvastatin response.

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Abbreviations

(SR-BI):

Scavenger receptor type B

MI:

Myocardial infarction

TC:

Total cholesterol

TG:

Triglyceride

LDL:

Low-density lipoprotein

HDL:

High-density lipoprotein

VLDL:

Very low-density lipoprotein

IHD:

Ischemic heart disease

(STEMI):

ST-elevation myocardial infarction

(NSTEMI):

Non-ST-elevation myocardial infarction

(SNP):

Single nucleotide polymorphisms

OR:

Odd ratio

CI:

Confidence interval

(ICIMT):

Internal carotid intimal-medial thickness

MI-b:

Myocardial infarction patients at baseline

MI-t:

Myocardial infarction patients after 20mg/ day/4 weeks of rosuvastatin therapy

BMI:

Body mass index

SBP:

Systolic blood pressure

DBP:

Diastolic blood pressure

MAF:

Minor allele frequency

HWE:

Hardy–Weinberg Equilibrium

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Authors and Affiliations

  1. Medical and Molecular Department, Biotechnology Research Center, Al-Nahrain University, Jadriya, Baghdad, Iraq

    Shaimaa Y. Abdulfattah, Huda Salman Alagely & Farah T. Samawi

Authors
  1. Shaimaa Y. Abdulfattah
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  2. Huda Salman Alagely
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  3. Farah T. Samawi
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Contributions

SYA Blood sample collection, genetic testing methodology, data collection, interpretation, statistics, and manuscript handling. HSA and FTS Investigation, writing, and editing.

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Correspondence to Shaimaa Y. Abdulfattah.

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Abdulfattah, S.Y., Alagely, H.S. & Samawi, F.T. Influence of the rs4238001 Genetic Polymorphism of the SR-B1 Gene on Serum Lipid Levels and Response to Rosuvastatin in Myocardial Infarction Iraqi Patients. Biochem Genet (2023). https://doi.org/10.1007/s10528-023-10613-4

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