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MicroRNAs, DNA damage response and ageing

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Abstract

Ageing is a multifactorial and integrated gradual deterioration affecting the most of biological process of cells. MiRNAs are differentially expressed in the cellular senescence and play important role in regulating of genes expression involved in features of ageing. The perception of miRNAs functions in ageing regulation can be useful in clarifying the mechanisms underlying ageing and designing of therapeutic strategies. The preservation of genomic integrity through DNA damage response (DDR) is related to the process of cellular senescence. The recent studies have shown that miRNAs has directly regulated the expression of numerous proteins in DDR pathways. In this review study, DDR pathways, miRNA biogenesis and functions, current finding on DDR regulations, molecular biology of ageing and the role of miRNAs in these processes have been studied. Finally, a brief explanation about the therapeutic function of miRNAs in ageing regarding its regulation of DDR has been provided.

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Acknowledgements

The Authors would like to thank Aging Reserch Institute of Tabriz University of Medical Science for fund suppord (Grant no: 62906) and Clinical Research Development Unit, Shohada Hospital, Tabriz University of Medical Sciences for kind advisory supports.

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Authors and Affiliations

  1. Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran

    Maryam Majidinia

  2. Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran

    Seyed Mostafa Mir & Bahman Yousefi

  3. Student Research Committee, Babol University of Medical Sciences, Babol, Iran

    Seyed Mostafa Mir

  4. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

    Mohammad Mirza-Aghazadeh-Attari

  5. Anesthesiology Research Team, Tabriz University of Medical Sciences, Tabriz, Iran

    Roghaieh Asghari & Ata Mahmoodpoor

  6. Stem Cell Center Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Hossein Samadi Kafil & Bahman Yousefi

  7. Institute of Research and Development, Duy Tan University, Da Nang, Vietnam

    Amin Safa

  8. Department of Immunology, Ophthalmology and ENT, School of Medicine, Complutense University, Madrid, Spain

    Amin Safa

  9. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Bahman Yousefi

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  1. Maryam Majidinia
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Majidinia, M., Mir, S.M., Mirza-Aghazadeh-Attari, M. et al. MicroRNAs, DNA damage response and ageing. Biogerontology 21, 275–291 (2020). https://doi.org/10.1007/s10522-020-09862-2

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