Abstract
Obesity is an induced health problem that human beings have been facing with non-optimal treatment so far. Humans are on average getting fatter with age, and obesity and aging interact each other to shorten lifetime and decrease life quality. Obesity also causes several aging related-disorders such as cancer, strokes, cardiovascular disease, high blood pressure and type 2 diabetes. So, the molecular connections between aging and obesity are promising targets for bio-medical researches and innovative therapies of many health problems. In this review, we discuss the findings of adipose p53 and Rb—two central molecular linkages between aging and obesity—on lipid metabolism and obesity.
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Acknowledgements
We would like to thank our colleagues especially Dr. Lien Nguyen (University of Florida, Gainesville, USA) for critical reading and helpful comments to improve the revised manuscript. We acknowledge all researchers who have contributed to our understandings of adipose p53 and Rb on fat metabolism and obesity. We apologize to other scientists for not directly citing their works that have contributed to the field because of space limitations. The DTC is a current postdoc under the SCIENTIA FELLOWS programme co-funded by Faculty of Medicine, University of Oslo and the EU Seventh Framework Programme (FP7) under Marie S. Curie scheme–People: Cofunding of Regional, National and International Programmes (COFUND), Grant Agreement No. 609020.
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Chu, DT., Tao, Y. Molecular connections of obesity and aging: a focus on adipose protein 53 and retinoblastoma protein. Biogerontology 18, 321–332 (2017). https://doi.org/10.1007/s10522-017-9698-4
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DOI: https://doi.org/10.1007/s10522-017-9698-4