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Polymorphisms in the superoxidase dismutase genes reveal no association with human longevity in Germans: a case–control association study

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Abstract

The role of superoxide dismutases (SODs) in aging and oxidative stress regulation has been widely studied and there is growing evidence that imbalances in these processes influence lifespan in several species. In humans, genetic polymorphisms in SOD genes may play an important role in the development of age-related diseases and genetic variation in SOD2 is thought to be associated with longevity. These observations prompted us to perform a case–control association study using a comprehensive haplotype tagging approach for the three SOD genes (SOD1, SOD2, SOD3) by testing a total of 19 SNPs in our extensive collection of 1,612 long-lived individuals (centenarians and nonagenarians) and 1,104 younger controls. Furthermore, we intended to replicate the previous association of the SOD2 SNP rs4880 with longevity observed in a Danish cohort. In our study, no association was detected between the tested SNPs and the longevity phenotype, neither in the entire long-lived sample set nor in the centenarian subgroup analysis. Our results suggest that there is no considerable influence of sequence variation in the SOD genes on human longevity in Germans.

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Acknowledgments

This study was funded by the DFG Excellence Cluster ‘Inflammation at Interfaces’, the INTERREG 4 A programme Syddanmark-Schleswig-K.E.R.N (with EU funds from the European Regional Development Fund) and the RESOLVE project (FP7-HEALTH-F4-2008-202047).

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  1. Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Schittenhelmstraße 12, 24105, Kiel, Germany

    Liljana Gentschew, Friederike Flachsbart, Rabea Kleindorp, Nandini Badarinarayan, Stefan Schreiber & Almut Nebel

  2. Clinic for Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany

    Stefan Schreiber

  3. Popgen Biobank, Christian-Albrechts-University, Kiel, Germany

    Stefan Schreiber

Authors
  1. Liljana Gentschew
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  2. Friederike Flachsbart
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  3. Rabea Kleindorp
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  4. Nandini Badarinarayan
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  5. Stefan Schreiber
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  6. Almut Nebel
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Corresponding author

Correspondence to Almut Nebel.

Additional information

Liljana Gentschew and Friederike Flachsbart have contributed equally to this study.

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Gentschew, L., Flachsbart, F., Kleindorp, R. et al. Polymorphisms in the superoxidase dismutase genes reveal no association with human longevity in Germans: a case–control association study. Biogerontology 14, 719–727 (2013). https://doi.org/10.1007/s10522-013-9470-3

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  • DOI: https://doi.org/10.1007/s10522-013-9470-3

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