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Studying the Proliferative Activity of Human Corneal Stromal Cell Populations

  • MORPHOLOGY AND PATHOMORPHOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

The proliferative activity of populations of stromal cells (fibroblasts) obtained from human corneal lenticles under conditions of their differentiation into keratocytes was studied. It was shown that during differentiation, the number of dividing fibroblasts and the frequency of divisions, and motor activity of these cells (speed of movement along the cell trajectory and the length of the trajectory) sharply decreased. These findings indicate a decrease in the proliferative activity of fibroblasts under conditions of their differentiation and transformation into keratocytes. A period of 17 days is sufficient for differentiation of corneal fibroblasts into keratocytes.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology — Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    N. A. Bondarenko, M. A. Surovtseva, I. I. Kim, K. Yu. Krasner & O. V. Poveshchenko

  2. S. N. Fedorov National Medical Research Center Multisectoral Scientific and Technical Complex “Eye Microsurgery”, Ministry of Health of the Russian Federation, Novosibirsk, Russia

    K. Yu. Krasner, A. N. Trunov & V. V. Chernykh

  3. Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    K. E. Orishchenko

Authors
  1. N. A. Bondarenko
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  2. M. A. Surovtseva
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  3. I. I. Kim
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  4. K. Yu. Krasner
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  5. K. E. Orishchenko
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  6. A. N. Trunov
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  7. V. V. Chernykh
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  8. O. V. Poveshchenko
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Corresponding author

Correspondence to N. A. Bondarenko.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 176, No. 7, pp. 122-127, July, 2023

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Bondarenko, N.A., Surovtseva, M.A., Kim, I.I. et al. Studying the Proliferative Activity of Human Corneal Stromal Cell Populations. Bull Exp Biol Med 176, 105–110 (2023). https://doi.org/10.1007/s10517-023-05976-y

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  • DOI: https://doi.org/10.1007/s10517-023-05976-y

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