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Skin Fibroblasts as the Object for Clinical Diagnosis of Parkinson’s Disease in Persons of Different Ages

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We compared the expression of Aβ42 peptide, τ-protein, and α-synuclein in the substantia nigra and skin fibroblasts of elderly and senile patients with Parkinson’s disease and subjects without neuropathology. Expression of markers in the studied tissues was assessed by immunohistochemical and immunocytochemical methods. The expression of Aβ42 peptide, τ-protein, and α-synuclein in the substantia nigra of elderly and senile patients with Parkinson’s disease was higher by 11-31 times than in subjects without neuropathology. In skin fibroblasts of patients with Parkinson’s disease, the expression of Aβ42 peptide and α-synuclein was 3-14 times higher than in subjects without neuropathology, and expression of τ-protein did not significantly differ in the studied groups. Thus, immunocytochemical analysis of the expression Aβ42 peptide and α-synuclein in skin fibroblasts can be a simple method of early diagnosis of Parkinson’s disease in elderly persons.

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Authors and Affiliations

  1. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia

    V. A. Zuev, A. S. Dyatlova, N. S. Lin’kova & I. M. Kvetnoi

  2. Institute of Experimental Medicine, St. Petersburg, Russia

    A. S. Dyatlova

  3. Peter the Great St. Petersburg State Polytechnic University, St. Petersburg, Russia

    N. S. Lin’kova

  4. Center of Immunology and Molecular Biomedicine, Faculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia

    N. N. Belushkina & V. A. Pal’tsev

Authors
  1. V. A. Zuev
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  2. A. S. Dyatlova
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  3. N. S. Lin’kova
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  4. I. M. Kvetnoi
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  5. N. N. Belushkina
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  6. V. A. Pal’tsev
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Corresponding author

Correspondence to N. S. Lin’kova.

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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 63-68, January, 2019

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Zuev, V.A., Dyatlova, A.S., Lin’kova, N.S. et al. Skin Fibroblasts as the Object for Clinical Diagnosis of Parkinson’s Disease in Persons of Different Ages. Bull Exp Biol Med 167, 177–181 (2019). https://doi.org/10.1007/s10517-019-04485-1

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  • DOI: https://doi.org/10.1007/s10517-019-04485-1

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