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Structural and Functional Analysis of the Spermatogenic Epithelium in Rats Exposed to Titanium Dioxide Nanoparticles

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We studied immunohistochemical and morphometric characteristics of the spermatogenic epithelium in rats against the background of peroral administration of nanoparticles containing titanium dioxide. Substantial degenerative changes in the spermatogenic epithelium were revealed: thinning, disorganization of layers, and detachment of sperm cells from the basement membrane. Immunohistochemical analysis revealed reduced proliferative activity and differentiation potential of epithelial cells, which was confirmed by changes in the expression of Ki-67 and c-kit markers. Our data attest to unfavorable effects of titanium dioxide nanoparticles on the structural and functional characteristics of the reproductive system in male rats leading to spermatogenesis disturbances.

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Authors and Affiliations

  1. Department of Human Physiology and General Biology, Faculty of Biology, Bashkir State University, Ufa, The Republic of Bashkortostan, Russia

    L. A. Sharafutdinova, A. M. Fedorova, S. A. Bashkatov & K. N. Sinel’nikov

  2. Department of Histology, Kazan State Medical University, Kazan, The Republic of Tatarstan, Russia

    V. V. Valiullin

Authors
  1. L. A. Sharafutdinova
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  2. A. M. Fedorova
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  3. S. A. Bashkatov
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  4. K. N. Sinel’nikov
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  5. V. V. Valiullin
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Corresponding author

Correspondence to L. A. Sharafutdinova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 8, pp. 241-245, August, 2018

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Sharafutdinova, L.A., Fedorova, A.M., Bashkatov, S.A. et al. Structural and Functional Analysis of the Spermatogenic Epithelium in Rats Exposed to Titanium Dioxide Nanoparticles. Bull Exp Biol Med 166, 279–282 (2018). https://doi.org/10.1007/s10517-018-4332-2

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  • DOI: https://doi.org/10.1007/s10517-018-4332-2

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