Experiments on random-bred albino mice showed that of β2-adrenoreceptor agonist hexaprenaline sulfate significantly reduced mortality of mice from experimental sepsis (intraperitoneal administration of E. coli) in 4 and 24 h after modeling by reducing blood levels of proinflammatory cytokines TNFα, IL-1β, and IL-6. The antagonist of β2AR ICI-118,551 eliminated this effect.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 6, pp. 674-677, June, 2017
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Zabrodskii, P.F., Gromov, M.S. & Maslyakov, V.V. Role of β2-Adrenoreceptors in Adrenergic Anti-Inflammatory Mechanism in Sepsis. Bull Exp Biol Med 163, 710–713 (2017). https://doi.org/10.1007/s10517-017-3886-8
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DOI: https://doi.org/10.1007/s10517-017-3886-8