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Plasma Level of hsa-miR-619-5p microRNA Is Associated with Prostatic Cancer Dissemination beyond the Capsule

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Bulletin of Experimental Biology and Medicine Aims and scope

Profiles of circulating microRNA in the plasma of patients with prostate cancer with pathomorphological stages pT2, pT3, and pT4 are analyzed. The level of circulating microRNA hsa-miR-619-5p is elevated in patients with extracapsular spreading of the tumor, increasing significantly from stage pT2 to stage pT4.

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References

  1. Osip’yants AI, Knyazev EN, Galatenko AV, Nyushko KM, Galatenko VV, Shkurnikov MY, Alekseev BY. Changes in the level of circulating hsa-miR-297 and hsa-miR-19b-3p miRNA are associated with generalization of prostate cancer. Bull. Exp. Biol. Med. 2017;162(3):379-382.

    Article  PubMed  Google Scholar 

  2. Chang CY, Leu JD, Lee YJ. The actin depolymerizing factor (ADF)/cofilin signaling pathway and DNA damage responses in cancer. Int. J. Mol. Sci. 2015;16(2):4095-4120.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Collazo J, Zhu B, Larkin S, Martin SK, Pu H, Horbinski C, Koochekpour S, Kyprianou N. Cofilin drives cell-invasive and metastatic responses to TGF-β in prostatecancer. Cancer Res. 2014;74(8):2362-2373.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Kim B, Srivastava SK, Kim SH. Caspase-9 as a therapeutic target for treating cancer. Expert Opin. Ther. Targets. 2015;19(1):113-127.

    Article  CAS  PubMed  Google Scholar 

  5. Knyazev EN, Fomicheva KA, Mikhailenko DS, Nyushko KM, Samatov TR, Alekseev BY, Shkurnikov MY. Plasma levels of hsa-miR-619-5p and hsa-miR-1184 differ in prostatic benign hyperplasia and cancer. Bull. Exp. Biol. Med. 2016;161(1):108-111.

    Article  CAS  PubMed  Google Scholar 

  6. Knyazev EN, Samatov TR, Fomicheva KA, Nyushko KM, Alekseev BY, Shkurnikov MY. MicroRNA hsa-miR-4674 in hemolysis-free blood plasma is associated with distant metastases of prostatic cancer. Bull. Exp. Biol. Med. 2016;161(1):112-115.

    Article  CAS  PubMed  Google Scholar 

  7. Makarova JA, Maltseva DV, Galatenko VV, Abbasi A, Maximenko DG, Grigoriev AI, Tonevitsky AG, Northoff H. Exercise immunology meets MiRNAs. Exerc. Immunol. Rev. 2014;20:135-164.

    PubMed  Google Scholar 

  8. Makarova JA, Shkurnikov MU, Wicklein D, Lange T, Samatov TR, Turchinovich AA, Tonevitsky AG. Intracellular and extracellular microRNA: an update on localization andbiological role. Prog. Histochem. Cytochem. 2016;51(3-4):33-49.

    Article  PubMed  Google Scholar 

  9. Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O’Briant KC, Allen A, Lin DW, Urban N, Drescher CW, Knudsen BS, Stirewalt DL, Gentleman R, Vessella RL, Nelson PS, Martin DB, Tewari M. Circulating microRNAs as stable blood-based markers for cancer detection. Proc. Natl Acad. Sci. USA. 2008;105(30):10,513-10,518.

    Article  CAS  Google Scholar 

  10. Mussnich P, Rosa R, Bianco R, Fusco A, D’Angelo D. MiR-199a-5p and miR-375 affect colon cancer cell sensitivity to cetuximab by targeting PHLPP1. Expert Opin. Ther. Targets. 2015;19(8):1017-1026.

    Article  CAS  PubMed  Google Scholar 

  11. Pritchard CC, Kroh E, Wood B, Arroyo JD, Dougherty KJ, Miyaji MM, Tait J.F, Tewari M. Blood cell origin of circulating microRNAs: a cautionary note for cancer biomarker studies. Cancer Prev. Res. (Phila). 2012;5(3):492-497.

    Article  CAS  Google Scholar 

  12. Shkurnikov MY, Knyazev EN, Fomicheva KA, Mikhailenko DS, Nyushko KM, Saribekyan EK, Samatov TR, Alekseev BY. Analysis of plasma microRNA associated with hemolysis. Bull. Exp. Biol. Med. 2016;160(6):748-750.

    Article  CAS  PubMed  Google Scholar 

  13. Skurnikov MY, Makarova YA, Knyazev EN, Fomicheva KA, Nyushko KM, Saribekyan EK, Alekseev BY, Kaprin AD. Profile of microRNA in blood plasma of healthy humans. Bull. Exp. Biol. Med. 2016;160(5):632-634.

    Article  CAS  PubMed  Google Scholar 

  14. Song J, Bai Z, Zhang J, Meng H, Cai J, Deng W, Bi J, Ma X, Zhang Z. Serum microRNA-21 levels are related to tumor size in gastric cancer patients but cannot predict prognosis. Oncol. Lett. 2013;6(6):1733-1737.

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Turchinovich A, Tonevitsky AG, Burwinkel B. Extracellular miRNA: a collision of two paradigms. Trends Biochem. Sci. 2016;41(10):883-892.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. BioClinicum Research Centre, Moscow, Russia

    M. Yu. Shkurnikov, Yu. A. Makarova, E. N. Knyazev, A. V. Galatenko & V. V. Galatenko

  2. P. A. Herzen Moscow Oncology Research Institute, Affiliated Branch of National Medical Research Radiology Center, Ministry of Health of Russia, Moscow, Russia

    M. Yu. Shkurnikov, E. N. Knyazev, K. A. Fomicheva, K. M. Nyushko & B. Ya. Alekseev

  3. Federal Research Institute of Health Organization and Informatics, Ministry of Health of the Russian Federation, Moscow, Russia

    V. I. Vechorko

Authors
  1. M. Yu. Shkurnikov
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  2. Yu. A. Makarova
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  3. E. N. Knyazev
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  4. K. A. Fomicheva
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  5. A. V. Galatenko
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  6. K. M. Nyushko
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  7. V. V. Galatenko
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  8. V. I. Vechorko
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  9. B. Ya. Alekseev
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Corresponding author

Correspondence to M. Yu. Shkurnikov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 4, pp. 473-475, April, 2017

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Shkurnikov, M.Y., Makarova, Y.A., Knyazev, E.N. et al. Plasma Level of hsa-miR-619-5p microRNA Is Associated with Prostatic Cancer Dissemination beyond the Capsule. Bull Exp Biol Med 163, 475–477 (2017). https://doi.org/10.1007/s10517-017-3831-x

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  • DOI: https://doi.org/10.1007/s10517-017-3831-x

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