We performed correction of endothelial dysfunction with phenol derivatives KUD-259 and KUD-974 containing heteroatomic and heterocyclic structures. Pharmacological activity of KUD-259 and KUD-974 surpassed that of L-norvaline, a non-selective arginase inhibitor.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 4, pp. 431-434, April, 2017
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Pokrovskii, M.V., Korokin, M.V., Kudryavtsev, K.V. et al. Study of Endothelial Protective Activity of Phenol-Derived Thrombin and Arginase-2 Inhibitors KUD-259 and KUD-974. Bull Exp Biol Med 163, 436–438 (2017). https://doi.org/10.1007/s10517-017-3822-y
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DOI: https://doi.org/10.1007/s10517-017-3822-y