Skip to main content

Advertisement

SpringerLink
Log in

Effect of Hepatitis C Virus Coinfection on the Content of CD4+ and CD8+ T Cell Subpopulations in HIV-Infected Patients Receiving Antiretroviral Therapy

  • VIROLOGY
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of hepatitis C virus coinfection on T cell subpopulations in HIV-infected patients receiving antiretroviral therapy. Coinfection with hepatitis C virus was followed by a decrease in the number of naive CD4+ T cells and an increase in the count of central CD8+ memory T cells in these patients. Hepatitis C virus had no effect on the number of CD4+ memory T cells (main target for HIV). This can explain the absence of strong negative effect of hepatitis C virus on the course of HIV infection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. I. Zherdeva, A. V. Kuznetsova, N. A. Gorovenko, E. V. Dubotolkina, N. N. Larina, E. A. Loifman, I. N. Starukhina, I. A. Tatarchenko, V. A. Aksutina, and V. P. Dyatlov, Clinical and epidemiological characteristics of HIV infection in the Khabarovsk Region: chronic viral hepatitis, tuberculosis, and other opportunistic infections. Dal’nevostoch. Zh. Infekts. Patol., No. 12, 87-94 (2008).

  2. N. G. Shmagel, K. V. Shmagel, and V. A. Chereshnev, Clinical aspects of inefficiency of highly active antiretrovirus therapy. Infektsion. Bol., 9, No. 1, 5-10 (2011).

    Google Scholar 

  3. S. H. Bajaria, G. Webb, M. Cloyd, and D. Kirschner, Dynamics of naive and memory CD4+ T lymphocytes in HIV-1 disease progression. J. Acquir. Immune Defic. Syndr., 30, No. 1, 41-58 (2002).

    Article  PubMed  Google Scholar 

  4. J. M. Brenchley, D. A. Price, and D. C. Douek, HIV disease: fallout from a mucosal catastrophe. Nat. Immunol., 7, No. 3, 235-239 (2006).

    Article  CAS  PubMed  Google Scholar 

  5. J. K. Flynn, G. J. Dore, G. Matthews, M. Hellard, B. Yeung, W. D. Rawlinson, P. A. White, J. M. Kaldor, A. R. Lloyd, and R. A. Ffrench, ATAHC Study Group. Impaired hepatitis C virus (HCV)-specific interferon-γ responses in individuals with HIV who acquire HCV infection: correlation with CD4(+) T-cell counts. J. Infect. Dis., 206, No. 10, 1568-1576 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. G. Greub, B. Ledergerber, M. Battegay, P. Grob, L. Perrin, H. Furrer, P. Burgisser, P. Erb, K. Boggian, J. C. Piffaretti, B. Hirschel, P. Janin, P. Francioli, M. Flepp, and A. Telenti, Clinical progression, survival, and immune recovery during antiretroviral therapy in patients with HIV-1 and hepatitis C virus coinfection: the Swiss HIV Cohort Study. Lancet, 356, 1800-1805 (2000).

    Article  CAS  PubMed  Google Scholar 

  7. R. Halwani, M. Doroudchi, B. Yassine-Diab, L. Janbazian, Y. Shi, E. A. Said, E. K. Haddad, and R. P. Sekaly, Generation and maintenance of human memory cells during viral infection. Springer Semin. Immunopathol., 28, No. 3, 197-208 (2006).

    Article  PubMed  Google Scholar 

  8. M. D. Hernandez and K.E. Sherman, HIV/hepatitis C coinfection natural history and disease progression. Curr. Opin. HIV AIDS, 6, No. 6, 478-482 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  9. S. Mehandru, M. A. Poles, K. Tenner-Racz, A. Horowitz, A. Hurley, C. Hogan, D. Boden, P. Racz, and M. Markowitz, Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J. Exp. Med., 200, No. 6, 761-770 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. A. H. Mohsen, P. Easterbrook, C. B. Taylor, and S. Norris, Hepatitis C and HIV-1 coinfection. Gut, 51, No. 4, 601-608 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. M. Potter, A. Odueyungbo, H. Yang, S. Saeed, and M. B. Klein, Canadian Co-infection Cohort Study Investigators. Impact of hepatitis C viral replication on CD4+ T-lymphocyte progression in HIV-HCV coinfection before and after antiretroviral therapy. AIDS, 24, No. 12, 1857-1865 (2010).

    Article  PubMed  Google Scholar 

  12. K. V. Shmagel, E. V. Saidakova, L. B. Korolevskaya, N. G. Shmagel, V. A. Chereshnev, D. D. Anthony, and M. M. Lederman, Influence of hepatitis C virus coinfection on CD4+ T cells of HIV-infected patients receiving HAART. AIDS, 28, No. 16, 2381-2388 (2014).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Perm State National Research University, Perm, Russia

    L. B. Korolevskaya, K. V. Shmagel, E. V. Saidakova, N. G. Shmagel, S. V. Slobodchikova & V. A. Chereshnev

  2. Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia

    L. B. Korolevskaya, K. V. Shmagel, E. V. Saidakova & S. V. Slobodchikova

  3. Perm Regional Center for Prevention of AIDS and Infectious Diseases, Perm, Russia

    N. G. Shmagel

  4. Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia

    V. A. Chereshnev

  5. Ural Federal University Named after the First President of Russia B. N. Yeltsin, Ekaterinburg, Russia

    V. A. Chereshnev

Authors
  1. L. B. Korolevskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. V. Shmagel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. V. Saidakova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. G. Shmagel
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. V. Slobodchikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. V. A. Chereshnev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to L. B. Korolevskaya.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 2, pp. 243-246, February, 2016

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Korolevskaya, L.B., Shmagel, K.V., Saidakova, E.V. et al. Effect of Hepatitis C Virus Coinfection on the Content of CD4+ and CD8+ T Cell Subpopulations in HIV-Infected Patients Receiving Antiretroviral Therapy. Bull Exp Biol Med 161, 281–283 (2016). https://doi.org/10.1007/s10517-016-3395-1

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-016-3395-1

Key Words

Search

Navigation