DNA comet assay showed that the level of DNA damage in the placental and embryonic tissues of rats with streptozotocin-induced diabetes mellitus increased on gestation days 14 and 20. Afobazole and betaine administered per os effectively decreased the level of genotoxic damage; afobazole was most efficient in doses of 10 and 50 mg/kg and betaine in a dose of 100 mg/kg.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 6, pp. 731-735, June, 2015
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Zabrodina, V.V., Shreder, E.D., Shreder, O.V. et al. Effect of Afobazole and Betaine on DNA Damage in Placental and Embryonic Tissues of Rats with Experimental Streptozocin Diabetes. Bull Exp Biol Med 159, 757–760 (2015). https://doi.org/10.1007/s10517-015-3068-5
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DOI: https://doi.org/10.1007/s10517-015-3068-5